OSLU Classes

14 May 2013 Leave a comment

Ozarks Self Reliant Living University will hold intermediate gardening classes this month, , Saturday May 18 at the Koshkonong Senior Cetner and Sunday May 19 at the Next Step 7^th Day Adventist Church in West Plains. All classes are from 1 pm to 3 pm and all classes are free.

OSLU provides free classes in life skills of past generations that are needed today to feed and care for our families, including gardening, food preservation, soap making, cheese and yogurt making, baking and many other skills for healthy happy living. For information call 417-264-2435.

New Study Shows “Leukemogenic” Properties of the Bt toxin

14 May 2013 2 Comments

by truthfarmer in Conspiracy, Control, Disease, FDA, food, Food Destruction Agency, GMO's Tags: bt, cancer, gmo, monsanto, Round Up

This is a redux on yet another study proving the inherent danger of the genetically modified food supply. With all of the proof behind the dangers of consumption of these aberrations, the only thing I can recommend is that every one grow everything they can and we must plant in defiance of the destruction of decency and integrity in our food. Please, do NOT feed your children this stuff!!! Here is the article:

A new study, yet to receive any media attention, reveals the “leukemogenic” properties of the Bt toxin biopesticides engineered into the vast majority of GMO food crops already within the US food supply.

Last September, the causal link between cancer and genetically modified food was confirmed in a French study, the first independent long-term animal feeding study not commissioned by the biotech corporations themselves. The disturbing details can be found here: New Study Finds GM Corn and Roundup Causes Cancer In Rats

Now, a new study published in the Journal of Hematology & Thromboembolic Diseases indicates that the biopesticides engineered into GM crops known as Bacillus Thuringensis (Bt) or Cry-toxins, may also contribute to blood abnormalities from anemia to hematological malignancies (blood cancers) such as leukemia.[i]

A group of scientists from the Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia/DF, Brazil set out to test the purported human and environmental biosafety of GM crops, looking particularly at the role that the Bt toxin found within virtually all GM food crops plays on non-target or non-insect animal species.

The research was spurred by the Brazilian Collegiate Board of Directors of the National Sanitary Surveillance Agency (ANVISA), who advocated in 2005 for evaluations of toxicity and pathogenicity of microbiological control agents such as Bt toxins, given that little is known about their toxicological potential in non-target organisms, including humans.

While Bacillus Thurigensis spore-crystals have been used since the late 1960’s in agriculture as a foliar insecticide, it was only after the advent of recombinant DNA biotechnology that these toxin-producing genes (known as delta endotoxins) were first inserted into the plants themselves and released into commercial production in the mid-90’s, making their presence in the US food supply and the bodies of exposed populations ubiquitous.

What the new study revealed is that various binary combinations and doses of Bt toxins are capable of targeting mammalian cells, particularly the erythroid (red blood cell) lineage, resulting in red blood cell changes indicative of significant damage, such as anemia. In addition, the study found that Bt toxins suppressed bone marrow proliferation creating abnormal lymphocyte patterns consistent with some types of leukemia.

The researchers also found that one of the prevailing myths about the selective toxicity of Bt to insects, the target species, no longer holds true:

It has been reported that Cry toxins exert their toxicity when activated at alkaline pH of the digestive tract of susceptible larvae, and, because the physiology of the mammalian digestive system does not allow their activation, and no known specific receptors in mammalian intestinal cells have been reported, the toxicity these MCAs to mammals would negligible [8,22,23]. However, our study demonstrated that Bt spore-crystals genetically modified to express individually Cry1Aa, Cry1Ab, Cry1Ac or Cry2A induced hematotoxicity, particularly to the erythroid lineage. This finding corroborates literature that demonstrated that alkali-solubilized Bt spore-crystals caused in vitro hemolysis in cell lines of rat, mouse, sheep, horse, and human erythrocytes and suggested that the plasma membrane of susceptible cells (erythrocytes, in this case) may be the primary target for these toxins [33]

The study also found:

1) That Cry toxins are capable of exerting their adverse effects when suspended in distilled water, not requiring alkalinization via insect physiology to become activated as formerly believed.

2) That a dose of Cry1Ab as low as 27 mg/kg, their lowest tested dose, was capable of inducing hypochromic anemia in mice – the very toxin has been detected in blood of non-pregnant women, pregnant women and their fetuses in Canada, supposedly exposed through diet.

3) Whereas past reports have found that Bt toxins are generally nontoxic and do not bioaccumulate in fatty tissue or persist in the environment, the new study demonstrated that all Cry toxins tested had a more pronounced effect from 72 hours of exposure onwards, indicating the opposite is true.

4) That high-dose Cry toxin doses caused blood changes indicative of bone marrow damage (damage to “hematopoietic stem cell or bone marrow stroma”).

The authors noted their results “demonstrate leukemogenic activity for other spore-crystals not yet reported in the literature.”

They concluded:

[R]esults showed that the Bt spore-crystals genetically modified to express individually Cry1Aa, Cry1Ab, Cry1Ac or Cry2A can cause some hematological risks to vertebrates,increasing their toxic effects with long-term exposure. Taking into account the increased risk of human and animal exposures to significant levels of these toxins, especially through diet, our results suggest that further studies are required to clarify the mechanism involved in the hematotoxicity found in mice, and to establish the toxicological risks to non-target organisms, especially mammals, before concluding that these microbiological control agents are safe for mammals.

Did you get that? Their conclusion is that it is premature to consider GM toxins to be safe in mammals. Billions have already been exposed to Bt toxins, in combination with glyphosate-based herbicide formulations such as Roundup, and yet, most biotech research scientists and industry regulators still claim they are unequivocally safe. This has much to do with the well-known relationship that biotech corporations like Monsanto have with so-called ‘check book’ science firms who are basically paid to obfuscate adverse health outcomes of their products, such as the GMO-Cancer link. [see: Monsanto-Funded Science Denies Emerging Roundup Cancer Link]

Consider also that the question of combined toxicity of Cry toxins and glyphosate-based residues within plants have not been sufficiently explored, and that glyphosate exposure has already been linked to non-Hodgkins lymphoma and hairy cell leukemia in the biomedical literature.[ii]

The reality is that we no longer have time to wait around for additional research to accumulate on the adverse health effects of GMOs, especially considering the biotech industry has far more capital to infuse into their own faux research on the topic.

Some, in fact, argue that we should not be waiting around for the corrupt legislative process to compel manufacturers to label GMOs, rather, we should be fighting to BAN THEM NOW, advocating for the precautionary principle before its too late.

In the meantime, you can join the growing movement to March Against Monsanto, occurring world wide on May 25th, as a way of expressing your desire for real change, as well as vote with your forks, the only immediately effective tool we have against biological and environmental gene-ocide articulated by the dominant GMO-based food system.

(from GeenMedInfo)

Monsanto Gets Another Gimme from US Federal Corporation

14 May 2013 Leave a comment

by truthfarmer in GMO's

Today’s news is rather depressing, folks. While I’ve long known the courts are a parody of “justice”, one must wonder what more we can do to preserve real food which gives health to people and other living things in this climate of tyranny. So…Monsanto wins again:

US Supreme Court finds for Monsanto in seed patent battle

Indiana grain farmer Vernon Hugh Bowman walks past the US Supreme Court on February 19, 2013 in Washington. The US Supreme Court has ruled in favor of Monsanto over Bowman, who was accused of having pirated the genetically-modified crops developed by the agribusiness giant.

AFP – The US Supreme Court ruled in favor of Monsanto Monday over an Indiana farmer accused of having pirated the genetically-modified crops developed by the agribusiness giant.

The high court’s unanimous decision focuses specifically on seed production, but experts say it may also have implications on intellectual property law in medicine, biotechnology and software.

The nine justices ruled that laws limiting patents do “not permit a farmer to reproduce patented seeds through planting and harvesting without the patent holder’s permission.”

The crux of the argument was over “patent exhaustion” which states that, after a patented item has been sold, the purchaser has “a right to use or resell that article,” Justice Elena Kagan explained in the court’s 10-page decision.

“Such a sale, however, does not allow the purchaser to make new copies of the patented invention,” she added.

At 2 pm (1800 GMT) on Monday after the ruling, Monsanto stock was down 1.1 percent at $106.94.

In a lawsuit filed in 2007, Monsanto had accused Vernon Hugh Bowman, a farmer, of infringing on its intellectual property rights by replanting, cultivating and selling herbicide-resistant soybean seeds it spent more than a decade developing.

The patented seed, which allows farmers to aerially spray Monsanto-made Roundup herbicide over their entire fields, was invented in 1996 and is now grown by more than 90 percent of the 275,000 US soybean farmers.

The farmer, 75, said he had respected his contract with Monsanto and purchased new Roundup Ready seeds each year for his first planting.

But he said hard times forced him to purchase a cheaper mixture of seeds from a grain elevator starting in 1999, which he used for his second planting.

The mixture included Roundup Ready soybeans, which Bowman was able to isolate and replant from 2000 to 2007.

“Under the patent exhaustion doctrine, Bowman could resell the patented soybeans he purchased from the grain elevator; so too he could consume the beans himself or feed them to his animals,” Kagan explained.

“But the exhaustion doctrine does not enable Bowman to make additional patented soybeans without Monsanto’s permission (either express or implied).

“And that is precisely what Bowman did,” she said.

The court found that the law rightly protects Monsanto from such a practice because, “were the matter otherwise, Monsanto’s patent would provide scant benefit.”

It upheld a lower court ruling demanding Bowman — whose lawyer has said is in dire economic straits — pay the $85,000 in damages Monsanto had sought.

Monsanto cheered the decision in a statement Monday.

“The Court’s ruling today ensures that longstanding principles of patent law apply to breakthrough 21st century technologies that are central to meeting the growing demands of our planet and its people,” Monsanto executive vice president David Snively said.

The company had been supported in court by the US government and, during the hearing, several justices already seemed disposed to rule in its favor.

Monsanto attorney Seth Waxman argued that Bowman was able to profit from the seed giant’s technology without having to pay for it, comparing the case to software piracy.

The high court agreed:

“If simple copying were a protected use, a patent would plummet in value after the first sale of the first item containing the invention,” Kagan wrote in the decision. “And that would result in less incentive for innovation than Congress wanted.”

Although the decision specifically limited its scope to the seed industry, “there’s one clause saying it may be broader,” patent expert Michael Ward told AFP.

“Where the replication is not inadvertent, as long the replication is not a necessary but incidental step, that decision would apply,” he explained.

Raw Milk is Not Local Food???

14 May 2013 3 Comments

by truthfarmer in food, No Food Rights, raw milk Tags: Dan Brown, food freedom, FTCLDF, local food, Maine, raw milk

A few years ago, the State of Maine passed several local food freedom ordinances and I was very excited by their success and commitment. Although there was a little problem with their ordinances, they were mostly very positive, and with Maine’s “home rule” authority, it looked like there might be hope in this type of action. First of all, it was local, and local seems to be one type of politics we can actually have a positive effect on. Well guess what? Apparently even if we get our freedom to choose our own food into statute or ordinance, it’s irrelevant to the the courts and the federally controlled State governments.

In Maine, the State went after a giant dairy farmer, Dan Brown, who milked one or two cows and sold his milk locally. Here’s the outcome from Farm To Consumer Legal Defense Fund:

Dan Brown Hearing in Maine Food Sovereignty Case: Judge Finds Raw Milk Not a ‘Local Food’

by admin on May 7, 2013

This is a rewrite of the April 30th original and the May 4th revision. More about the Case

In an incredible decision rendered on May 1st, the Hancock County Superior Court ruled against farmer Dan Brown on his motion for summary judgment. The Court instead granted summary judgment in favor of the State of Maine and issued an injunction enjoining Mr. Brown from selling raw milk and other food products from his farm stand.

The State had alleged that Dan was (1) selling raw milk without being in possession of a milk distributor’s license, (2) selling raw milk without having the necessary warning label, and (3) selling other foods prepared in his home kitchen without being in possession of a retail food license. Dan had argued that for over 30 years the Department of Agriculture had a policy of allowing small, unlicensed milk producers like him sell raw milk from their farm as long as they did not advertise or solicit the sale. He also argued that the Town of Blue Hill, Maine’s local ordinance exempted him from licensing requirements. Dan was represented by General Counsel Gary Cox and his Ellsworth, Maine co-counsel Sandy Collier who argued the case on his behalf.

Blue Hill’s local ordinance provides, in part, that local food produced by a farmer and sold to a consumer for home consumption need not be licensed or inspected. The Court, however, concluded that “nothing in the Blue Hill ordinance clearly states that the town intended to include milk within the definition of local food.” What’s clear is that the judge disregarded the definitions section of the Blue Hill Ordinance:

(c) “Local Foods ” means any food or food product that is grown, produced, or processed by individuals who sell directly to their patrons through farm-based sales or buying clubs, at farmers markets, roadside stands, fundraisers or at community social events.

(d) “Processor ” means any individual who processes or prepares products of the soil or animals for food or drink.

(e) “Producer ” means any farmer or gardener who grows any plant or animalfor food or drink.

FTCLDF member Dan Brown flanked by Attorneys
Gary Cox and Sandy Collier

Dan’s case has been described as a test case in Maine, a state where several local food sovereignty ordinances have been passed in an effort to allow local control over the production, distribution and consumption of local foods. Unfortunately, the Court’s ruling is another example of why the public citizenry loses faith in government when it cannot obtain redress from the judicial system and why more farmers and consumers are resorting to civil disobedience as a means of asserting their rights.

A penalty hearing has been set for May 16th at 9:00 am. At that time the court will determine the appropriate amount of civil penalty to be imposed for the violations alleged in the State’s complaint.

Vernon Herschberger Trial

14 May 2013 Leave a comment

by truthfarmer in Uncategorized

Vernon Hershberger Trial

Location:

Sauk County Courthouse Baraboo WI

Date:

Monday, May 20, 2013 – 9:00am to Friday, May 24, 2013 – 4:00pm

Wisconsin farmer, Vernon Hershberger is facing criminal charges for feeding his community. Vernon supplies wholesome food to a private food club of 200 members. The outcome of his trial will set precedent for all food clubs around the country! If Vernon is found guilty, not only could he go to prison for more than a year, we will see criminal charges, or the threat of criminal charges, used to shut down buying clubs around the country and limit the food choices of peaceful Americans!

While Vernon is on trial in the courtroom, raw milk is on trial in the court of public opinion. Join us for a “Grow Your Food Freedom” meeting and networking event happening in conjunction with the trial. Notable speakers/activists from around the country will be sharing their knowledge at this community event. There will be movie screenings in the evenings. The Grow Your Food Freedom event will be at the Al Ringling Theater across the street from the courthouse. (schedule below) Local/real foods lunches and dinners will be available to purchase. Please join us! Sponsored by the Farm Food Freedom Coalition FarmFoodFreedom.org

Join the facebook event

Common Core and the Threat to Homeschooling

13 May 2013 3 Comments

by truthfarmer in Uncategorized

As many of you know, we are proponents of home school, and while it isn’t an area of major activism for me, it is terribly important to me that this not be infringed upon. Well, it looks like Common Core is trying to co-opt this area of our lives. Here is a good article that explains a lot about the issue:

Thank you all for your wonderful comments, emails, and facebook messages regarding our post on the Common Core Curriculum (What is Happening To You Child’s Education? The Dangers of Common Core). I had planned on putting the information out there and then moving on with our homeschooling series. I have some fantastic posts by our guest bloggers in the cue, waiting to be published, but I feel like there needs to be a brief follow-up to our introduction on the Common Core.

How Does The Common Core Affect Homeschoolers?

The more that I read and study, the more convinced I am of the extreme detriment that the Common Core (CC) poses, not just to our children and our educational system – but to our country.

There are a few questions and comments that I have received this past week, some ranging from fear, and some from outright astonishment that I would even propose that CC presents a risk. I want to, as succintly as possible, answer some of these…

The Common Core is being introduced into the PUBLIC school, so if I’m homeschooling, I don’t need to worry, right?

WRONG. The CC is being adopted by 45 of the 50 states, including the District of Columbia, and it’s goal is NOT educational excellence. One look at the standards and examples that we detailed in our previous post will undeniably confirm that. The goal of Common Core is CONTROL. The government is seeking to Nationalize educational standards, which goes COMPLETELY against that 10th Amendment of the Constitution, which outlines education as being within the scope of the State government, not the Federal government. If the States decide not to adopt CC, they will not be granted federal dollars, so although it’s not a mandate, it’s a mob version of law via monetary coercion.

Furthermore, homeschoolers will eventually need to meet the same educational standard and use CC approved/aligned curricula because the SATs, State tests and GEDs will all be modified to fit the new CC standards.

(Full article here)

How Many Reasons Do You Need to Avoid Soy?

10 May 2013 Leave a comment

by truthfarmer in GMO's Tags: gmo babies, problems with soy, soy powder

This is a great article from Sarah, the Healthy Home Economist. Please read it and share with all of your friends. The fact that so many illnesses/syndromes have proliferated since GMO’s were allowed to masquerade as food is enough to give anyone with observational skills serious pause.

With all the loads of scientific data available that soy is not a healthy part of anyone’s diet, it shocks me how many folks are still on the “soy is good for you” bandwagon – even people who should know better like your doctor!

I just got an email from a reader the other day who had been to multiple doctors, both holistic and conventional, and all but one of them were telling her that plenty of soy in her diet would help her menopause symptoms.

Be careful folks. It’s dangerous out there! You really need to do your research and be on your toes at all times when it comes to nutritional advice even from someone in a white coat!

For those of you who just sat down because you are so taken aback by the notion that soy is not actually the healthfood you thought it was, here are 170 scientific reasons to back up this assertion.

Please note that fermented soy in small, condimental amounts as practiced in traditional Asian cultures is fine for those who have healthy thyroid function. Only miso, tempeh, natto and soy sauce (IF traditionally brewed) fall under this category. In addition, if you want to sprinkle a few edamame on your salad or have a few small cubes of tofu in your miso soup from time to time, that is fine too. Just don’t make it a regular part of your diet!

If you have any sort of thyroid issues going on, however, it is really the best policy to avoid all soy all the time as soy is a potent goitrogen (thyroid suppressor) even if fermented.

Soy Wake Up Call #1

A 1991 study found that eating only 2 TBL/day of roasted and pickled soybeans for 3 months to healthy adults who were receiving adequate iodine in their diet caused thyroid suppression with symptoms of malaise, constipation, sleepiness, and goiters (Nippon Naibunpi Gakkai Zasshi 1991, 767: 622-629)!

Still think munching on edamame instead of popcorn is a healthy habit?

Soy Wake Up Call #2

Six premenopausal women with normal menstrual cycles were given 45 mg of soy isoflavones per day. This is equivalent to only 1-2 cups of soy milk or 1/2 cup of soy flour! After only one month, all of the women experienced delayed menstruation with the effects similar to tamoxifen, the anti-estrogen drug given to women with breast cancer (American Journal of Clinical Nutrition 1994 Sep;60(3):333-340).

Soy Wake Up Call #3

Dietary estrogens in the form of soy foods were found to have the potential to disrupt the endocrine system with the effects in women similar to taking the breast cancer drug tamoxifen (Proceedings of the Society for Experimental Biology and Medicine 1995 Jan;208(1):51-9).

Soy Wake Up Call #4

Estrogens consumed in the diet at low concentrations were found to stimulate breast cells much like DDT to increase enzymatic activity which leads to breast cancer (Environmental Health Perspectives 1997 Apr;105 (Suppl 3):633-636).

Soy Wake Up Call #5

The soy isoflavones genistein and daidzein appear to stimulate existing breast cancer growth indicating risk in consuming soy products if a woman has breast cancer. (Annals of Pharmacotherapy 2001 Sep;35(9):118-21).

Soy Wake Up Call #6

Direct evidence that soy isoflavones genistein and daidzein suppress the pituitary-thyroid axis in middle-aged rats fed 10 mg soy isoflavones per kilo after only 3 weeks as compared with rats eating regular rat chow (Experimental Biology and Medicine 2010 May;235(5):590-8).

Soy Wake Up Call #7

Don’t eat soy when you are pregnant ladies! Scientific research has shown that the developing male fetus which is exposed to soy phytoestrogens may suffer from higher susceptibility to prostate cancer later in life (Prostate 1994;24(2):67-78).

Soy Wake Up Call #8

Keep that soy away from your daughters! Dietary genistein (soy phytoestrogen) in developing female rats had the effect of significantly accelerated puberty (Toxicol Sci 1999 Oct;51(2):236-44).

Soy Wake Up Call #9

Hey guys! Soy protein powder strips your masculinity! A study of 12 men aged 18 years and older experienced a 19% drop in serum testosterone in only 28 days when supplemented with 56 grams of soy protein powder over that same time period (Prev 2007;16:829–33).

Soy Wake Up Call #10

Do NOT feed soy formula to your babies! Female newborns who are orally exposed to genisin, the glycosylated form of genistein (soy phytoestrogen) experienced harm to the reproductive system in the form of “delayed vaginal opening… abnormal estrous cycles, decreased fertility, and delayed parturition.” (Environmental Health Perspective 2009 Dec;117(12):1883-9).

Convinced yet? I don’t know about you, but ten reasons is plenty for me! Still interested to see the remaining 160 reasons? My friend Dr. Kaayla Daniel, author of the must read The Whole Soy Story, has compiled the rest of the list for you if you click here.

Why??? Glow in the Dark Sheep, and Dogs and Cats Oh My

06 May 2013 1 Comment

by truthfarmer in Animal Welfare, GMO's, Uncategorized Tags: dog, glow in the dark cat, gmo, sheep

I guess I need to create a new category for posts. It will be called Daily Atrocities. Just because something can be done, does not mean that it should be done, but it seems scientists, politicians, and corporations funding these entities, have never heard that old adage. Or if they have heard it, they dismissed it as archaic nonsense.

It strikes me that nearly every form of mammalian genetic modification involves what is scripturally an unclean animal in one way or another. Inserting human genes into goats and cows, eel fish into salmon (I know, that isn’t a mammal), mice into pigs, jelly fish into pigs and cats and dogs and sheep. Sheesh. If this is considered the future of farming, I have to find a different name for what it is I want to do.

I’m not against technology, but this stuff is almost convincing me to become a Luddite.

Scientists in Uruguay Genetically Engineer Sheep to Glow Under UV Light

by Morgana Matus, 05/01/13

filed under: Animals, green technology

When you can’t sleep and need to count sheep to drift off, try wrapping your brain one of these eerie glowing lambs from South America. Scientists from the Animal Reproduction Institute of Uruguay (IRAUy) have genetically engineered nine animals to light up under UV light by incorporating a gene from the Aequorea victoria jellyfish. The research is intended to help easily identify genetically modified processes in animals.

IRAUy, connected to the Genetically Modified Animals Unit of the Pasteur Institute, has raised a flock of nine “brilliant lambs” that they have engineered to glow green under ultra-violet light. While most animal engineering is occupied with modifying organisms to produce compounds useful to humans through their milk, such as growth hormone or insulin, the project was intended to solely refine methods of manipulation.

“We did not use a protein of medical interest or to help with a particular medicine because we wanted to fine-tune the technique. We used the green protein because the color is easily identifiable in the sheep’s tissues,” Alejo Menchaca, the head of the research team told the South Atlantic News Agency. “Our focus is generating knowledge, make it public so the scientific community can be informed and help in the long run march to generate tools so humans can live better, but we’re not out in the market to sell technology.”

The project raises a myriad of ethical questions, ranging from whether or not jellyfish genetics belong in a grazing mammal, to what the long-term implications of altering an established genome will affect the well-being of both animals and humans. The team at IRAUy insists that the sheep behave normally and are closely monitored. Yet, despite appearing to function without incident, the full consequences of furthering such research has yet to be seen. The scientists hope to trigger the interest of the pharmaceutical industry, opening up a new avenue of debate as to the safety and moral ramifications of engineering animals to produce substances intended for human health.

Jellyfish Genes Make Glow-in-the-Dark Cats

By David Biello | September 12, 2011 | 10

First there were glow-in-the-dark fish, then rats, rabbits, insects, even pigs. And, now, researchers have inserted the jellyfish genes that make fluorescent proteins into Felis catus, or the common household cat.

The goal was just to make sure that the researchers could successfully insert novel genes into the cats. Past efforts at cloning and injecting DNA into fertilized cat embryos, among other genetic modification techniques, had failed. But the good doctors at the Mayo Clinic and Yamaguchi University in Japan succeeded by injecting a lentivirus bearing the novel genetics directly into unfertilized cat eggs. (Human immunodeficiency viruses 1 and 2 (HIV-1 and HIV-2), feline immunodeficiency virus (FIV) and simian immunodeficiency virus (SIV) are all lentiviruses, named for their slow incubation period.)

The result is visible to the naked eye (under blue light).

The goal is to use genetically modified cats as a better proxy for human diseases. After all, FIV plagues cats in much the same way that HIV plagues people. For that reason, cats can serve as useful animal models for learning more about the human version of the disease. The researchers, or their colleagues, plan to continue manipulating the cat genome to test potential gene therapies for HIV and other potential cures for AIDS.

But it’s also only a matter of time until a night-glowing cat (say goodbye to nightlights and tripping over the cat!) becomes a breed and joins the GloFish at the pet store.

Crimes Against Humanity…and Chickens

05 May 2013 8 Comments

by truthfarmer in Control, Enforcement, farm loss, food shortage Tags: Criminal chickens, Garden City, property rights, Randy Zellinger

I have copied the entire post below from this blog because it is terrifically important that people become aware of type of thing and work to either change these kinds of ridiculous laws in their cities and towns or orchestrate mass civil disobedience to annihilate these acts of State Sponsored Terrorism on Citizens. Please read, share and get involved in your surroundings:

Garden City, MI: Man sentenced to jail time on the CRIMINAL charge of keeping chickens!

Guys, you really can’t make this sort of stuff up. Randy Zeilinger, a Garden City MI resident, has been found guilty on the CRIMINAL charge of keeping chickens.

Think about that for a minute. A criminal charge follows you for your entire life. A criminal charge must be reported on job applications. A criminal conviction is reported to state and federal agencies.

The sentence is:

30 days in jail
6 months of reporting to probation
$905 in fines
Pay for the court appointed attorney
Comply with all city ordinances

But the honorable Judge Hammer was “nice” and suspended the jail time. However, if Randy fails on any of the above details he will be thrown in jail. That was clearly stated.

A few days after conviction, Randy began receiving new ordinance violations in the mail. These include a violation for keeping a wild skunk, a vandalized porch and peeling paint on his garage. The Garden City Ordinance Officer has indicated that he will be visiting Randy often and writing violations for anything that he can. Randy will likely face another year of bi-monthly court appearances.

Synopsis of Randy’s story (full story here):

From Randy: ‘I purchased my home in 2000. I started moving in around March of the same year. I moved my bee hives at the same time and was immediately confronted by a neighbor who called the police. The attending officer said that bees were OK if I kept them in my own yard. In hind sight, I should have noted the complaint and resulting dialog. However, I thought that I was within my rights based on the Michigan state law, often referred to as the “Right to Farm Act”. http://legislature.mi.gov/documents/mcl/pdf/mcl-Act-93-of-1981.pdf In fact, I was (am) covered by this law. Over the next ten years or so, this same neighbor lodged numerous complaints against me. City officials recognized that these complaints were baseless in nature and merely a case of “everyone has one of THOSE neighbors”. ‘

*A note on the Michigan Right to Farm Act: it supersedes local city/town ordinances. While I (Laura) opted to work with my city to have an ordinance included in our muni code allowing for chickens, technically I didn’t need to. Taken from MRTFA : (6) Beginning June 1, 2000, except as otherwise provided in this section, it is the express legislative intent that this act preempt any local ordinance, regulation, or resolution that purports to extend or revise in any manner the provisions of this act or generally accepted agricultural and management practices developed under this act. Except as otherwise provided in this section, a local unit of government shall not enact, maintain, or enforce an ordinance, regulation, or resolution that conflicts in any manner with this act or generally accepted agricultural and management practices developed under this act. This section affirms your Michigan right to continuation business farming operating within generally accepted agricultural and management practices (GAAMPS) guidelines and supersedes any city laws that may forbid said farming. For your reference, Shelby Township v. Papesh is a similar case and may assist in your legal determinations.

Here’s where things start falling apart for Randy:

In 2009 he acquires some chickens and ducks. After a year of keeping chickens and ducks, he rehomed the ducks after a neighbor complained to him about them.
In 2012, the same neighbor that complained about the ducks complained to Randy about the chickens. This neighbor posits that “he never asked her permission to have them (the chickens)”.
The neighbor who complained to Randy about his chickens also complained to him about: his koi and frog pond & a tree growing in his front yard. This neighbor called the city and demanded that they cut down Randy’s tree, which the city refused to do (thankfully).
The complaining neighbor, now incensed, files a legal complaint about Randy’s chickens. The Garden City ordinance officer cites Randy with keeping chickens, despite not seeing any signs of chickens on Randy’s property. The ordinance officer visited Randy’s farm on March 21, 2012. Several weeks later, Randy received a post card from 21^st District Court to appear for a zoning violation dated March 23, 2012.

The ordinance violation was written against a 50 year-old ordinance.

§ 90.01 PETS; SALE OF ANIMALS; PROHIBITIONS.

(A) No person shall keep or house any animals or fowl within the city except dogs, cats, canaries, or animals commonly classified as pets, customarily kept or housed inside dwellings as household pets.

(B) No person shall sell, or offer for sale, barter, or give away baby chicks, rabbits, ducklings, or other fowl as pets or novelties, whether or not dyed, colored, or otherwise artificially treated. This division shall not be construed to prohibit the display or sale of natural chicks or ducklings in proper brooder facilities by hatcheries or stores engaged in the business of selling the same to be raised for commercial purposes.

(Ord. 11-006, passed 4-25-11)

Now, here’s where things get surreal.

Mid-April, Randy appears in court before the Honorable Judge Richard L, Hammer, Jr. of the 21^st. District Court. The judge sent Randy back to meet with the city prosecutor, Timothy L. Cronin (P26417).
During this meeting, Mr. Cronin said that if Randy wanted a farm then he should move out of the city. When Randy replied that he was unable to move, he said that chickens were not allowed in the city and if Randy pursued the case that he would “make an example” of him. He went on to say that the mayor did not want farm animals in the city and that he took direction from the mayor. He further indicated that Randy was not welcome in this city and he would be foolish to continue the case. At no time did he indicate that a compromise could be reached.
Randy appears at city council meetings while his court dates are repeatedly postponed, speaking in favor of allowing backyard chickens in Garden City. After one meeting, reporter Sue Buck runs a story in the June 24 2012 issue of the Garden City Observer on Randy and 2 others who spoke positively about keeping backyard chickens. The other 2 individuals cited in the paper received chicken keeping code violation notices in the mail immediately after.
Randy’s complaining neighbor vandalizes his property and calls the city to lodge a complaint about it being in disarray.
An anonymous call is made complaining about a rooster crowing. Randy has no rooster.
Randy’s complaining neighbor drives to Westland to visit his 80 year old mother, demanding that she force her son to do what they ask (remove chickens, cut down tree, etc). The woman is fearful and traumatized.
By the end of July 2012, the police have been out to Randy’s house a half a dozen times. Each time was a response to an anonymous complaint called in. No charges were leveled.
In August 2012, police respond to a complaint about a skunk found in the complaining neighbors yard. Three police officers in two cars responded to the call. They insisted that Randy do something about the skunk in the neighbor’s yard. The neighbor had mentioned that the skunk had come from Randy and that he had sent it to spray them. The armed police officers force Randy from his house to go retrieve a wild skunk- which turned out to be a baby skunk with barely open eyes. Randy retrieves the skunk from under the neighbors car, receives a ticket for having an unlicensed animal, and is left with the task of getting the baby skunk to a wildlife rehabilitator.
Skunk cops are on patrol!

In fall 2012 Randy finally gets closer to a court date, is allowed a court appointed attorney. Initially, the court told the defending attorney that the case was about the skunk but in reality, the case was about keeping chickens and the Michigan Right to Farm Act.

Randy’s appointed attorney, James M. Jernigan (P-57035) took the case even though he was somewhat skeptical at first. Randy explained the RTFA and how it applied to his case. Randy explained the GAAMPs, the history of the law and cited other cases that had been tried and eventually reached the Michigan Court of Appeals.
Randy’s case is repeatedly delayed due in part to another chicken keeper case being tried in the 21^st District Court. That case was actually moved to the city of Wayne and presided by city of Wayne Judge Laura R. Mack, because Judge Hammer was recused. That case is City of Garden City v. Pete Santeiu (Case No, 12 GC 1547 OM). That case was dismissed by Judge Mack. Signed and dated: January 7, 2013.
In February 2013, the Garden City prosecution amended Randy’s case to be a criminal complaint rather than the original animal ordinance violation.
Randy’s jury trial is set for April 11 & 12th 2013.
Several points of law were disallowed based on the fact that this was a criminal charge and not merely a zoning violation. Case law, Court of Appeals decisions and opinions were discounted. The ruling of Judge Mack (representing the same court, and for the same sort of case) was disallowed.
Several individuals came to testify for Randy’s defense, stating he was a good neighbor and that the chickens were not a nuisance in any way.
Prosecution presented documents (not entered into evidence) that challenged Randy’s claim of GAAMP compliance. In a nutshell, it was argued that by Randy exceeding the GAAMP protocols, he was not “following” the GAAMPs. Thus if he wasn’t following GAAMPs then he was not compliant and not protected by MRTFA.

This case is disturbing on so many levels. If you’d like to read about it in Randy’s own words, click here.

I urge you all to share this far and wide- it’s gotten NO media attention here in Michigan, and likely won’t without a grassroots effort. Also, if you’d like to share your thoughts on this situation, please direct them to the Garden City mayor and councilmembers, as well as the senatorial representatives. Follow us on Facebook for updates on Randy’s story as it continues to unfold.

UPDATES:

Randy was interviewed on Fox 2 Detroit. His neighbor chimed in as well, and showed just the sort of behavior you’d never want to see from a neighbor, even if you didn’t have chickens.

Killing Us Softly – Glyphosphate, Deadly Convenience

02 May 2013 1 Comment

by truthfarmer in Consolidation, Conspiracy, Control, Dairy, Disease, FDA, food, food safety, Uncategorized, USDA Tags: agribusiness, disease, glyphosphate, GMO's, monsanto, Round Up, Seralini

Recently, I posted a link to a study heavily referenced in the following articles. That study actually cinched me up, when not much does any more. The issue I keyed on was the actual change of messenger RNA upon exposure, not limited to ingestion, of the lovely GMO’s that are so prevalent in our food supply now. However, there is a lot more information in the study than just that, and Heidi Stevenson has done a tremendous service to all of mankind by relating the study to us in a three part series on glyphosphate.

Please people, read this. Share it. Give it to mothers who are feeding their babies commercial formula, to farmers growing GMO crops, your local Health Board, doctors, and of course, advocates for real food. I know this is long, but here is a link to a pdf of the three articles so you can print it out and read it at your leisure.

While the truth may be ugly, and unfathomable to those of us who actually love life, it is paramount that we have as much information as possible so we can make decisions based on facts and not simply convenience.

Glyphosphate- Killing Us Softly, Monsanto Style

Glyphosate is assumed to be safe for humans. As a result, it’s become the world’s best-selling herbicide. However, a groundbreaking study documents that it may actually be fueling the plague of chronic & immune diseases, including cancer and autism. This study documents the underlying systemic damage produced by glyphosate, then discusses how that damage leads to specific diseases.

by Heidi Stevenson

This article is split into three parts. This is Part 1, Glyphosate: Chronic Disease Degeneration. It gives an overview and then goes on to discuss the primary findings of a new study about the human effects of Monsanto’s herbicide, glyphosate. Part 2, titled Glyphosate: Disease Creator, discusses specific diseases, applying the basic harms produced by glyphosate and showing how they lead to each disease. Part 3, titled Glyphosate: A Trajectory of Human Misery, discusses glyphosate’s use throughout the world and then draws conclusions.

Monsanto’s herbicide, glyphosate, has become virtually ubiquitous based on a presumption of harmlessness in humans. In spite of noxious and aggressive superweeds that have developed in response and a host of reports citing harm and potential harm to the environment and farm animals, this premise of innocence has resulted in its use nearly everywhere. Because of that same image of innocence, its use has multiplied astronomically.

However, a new report from the journal Entropy turns the proposition of glyphosate’s innocence in human health upside down. An exhaustive review of existing research in which 287 studies were reviewed, coupled with irrefutable logic, produces a frightening picture of the reality: Glyphosate may be the single most devastating substance ever introduced into agribusiness. As the authors, Anthony Samsel and Stephanie Seneff, concluded:

Glyphosate is likely to be pervasive in our food supply, and, contrary to being essentially nontoxic, it may in fact be the most biologically disruptive chemical in our environment.

The range of diseases that can be associated with glyphosate is frightening. Its biological effects are so primary that virtually every bodily system—if not every one—is adversely affected. The authors state:

Our systematic search of the literature has led us to the realization that many of the health problems that appear to be associated with a Western diet could be explained by biological disruptions that have already been attributed to glyphosate. These include digestive issues, obesity, autism, Alzheimer’s disease, depression, Parkinson’s disease, liver diseases, and cancer, among others. While many other environmental toxins obviously also contribute to these diseases and conditions, we believe that glyphosate may be the most significant environmental toxin …

Glyphosate’s Metabolic Disruptions

The study documents that glyphosate disrupts several significant basic biological processes in humans with devastating results. Certain primary functions at the most basic levels are disrupted or diverted. These include:

Disruption of the shikimate pathway in gut biota.
Disruption of sulphate transport
Increase in Flavonoid Synthesis
Disruption of cytochrome P-450 enzymes

This section will explain and discuss each of these.

Shikimate Pathway Disruption

Glyphosate is believed to operate by disrupting the shikimate (pronounced shə kih mut) pathway in plants, a process for manufacturing a group of amino acids called aromatic (though the term has nothing to do with odor). These include phenylalanine, tyrosine, and tryptophan. Aromatic amino acids are required for a plant’s survival.

It’s been assumed that glyphosate is harmless in humans because the shikimate pathway does not exist in any animal. However, the shikimate pathway does exist in bacteria, including those in the mammalian gut. Until fairly recently, the importance of gut biota in health has largely been ignored. However, it’s now understood to be key in many aspects of the body’s function.

Gut bacteria are in a symbiotic relationship with the body. They digest food, synthesize vitamins, detoxify foreign substances, and are key in immune system function and gut permeability. Thus, anything that interferes with the shikimate pathway has the potential of causing severe harm.

Disruption of Sulphate Transport

Sulphate transport, the method by which sulphate is moved into and out of cells, is a delicate balance. When glyphosate is present, this balance becomes a tightrope walk. The problem is that both sulphate and glyphosate are kosmotropes, which can have a devastating impact on the blood.

A kosmotrope is a substance that can cause water to become gelled. Too much sulphate in blood can turn it into sludge, so it cannot circulate and bring nutrients and oxygen to cells or remove waste. Therefore, transport of sulphate is always a balancing act between cellular requirements and blood viscosity.

However, when glyphosate is added to the picture, the risk is even greater. Glyphosate is also a kosmotrope, which makes it significantly more difficult for sulphate to be transported where it’s needed. As a result, sulphate transport is disrupted in the presence of glyphosate.

Increase in Flavonoid Synthesis

Glyphosate interferes with synthesis of the aromatic amino acid, tryptophan, instead favoring the production of flavonoids by as much as 20 times normal. While flavonoids are generally believed to be health-inducing, Samsel & Seneff’s paper presents the likelihood that the picture is far more complex, and they propose a role for them in sulphate transport in the presence of glyphosate.

It’s known that, in both plants and microbes, glyphosate induces synthesis of two kinds of phenols: monophenolic compounds and polyphenolic flavonoids. Although monophenols are known to be toxic, flavonoids are generally thought to be beneficial for heath. However, their metabolic mechanisms are unknown.

Carbon rings are part of the molecular structure of phenols. Molecules with carbon rings have a special capability. They can diffuse the effects of kosmotropes. Therefore, phenols, including monophenols and flavonoids, are able to diffuse the effects of sulphate by binding to it and escorting it through the bloodstream.

Sulphate transport comes under pressure in the face of glysophate’s kosmotropic gelling effect on the blood. Therefore, aromatic amino acids may be oxidized into phenolic compounds to compensate, that is, to provide more phenols for sulphate transport.

However, once a phenol has delivered its sulphate, it becomes highly toxic. Sulphate-free phenols are destructive to phospholipids and DNA.

Therefore, to fulfill the more pressing need of sulphate transport, authors Samsel & Seneff propose that flavonoids are synthesized instead of tryptophan. That is, because of flavonoids’ ability to counter the kosmotropic effects of glyphosate, they are produced at the expense of tryptophan.

They propose that, in the presence of glyphosate, flavonoids and phenols can transport sulphur from the gut to the liver, and then return to the gut by way of the hepatic portal vein to repeat the process. However, once a phenol has given up the sulphate anion in the liver, it becomes toxic, over time causing damage to the liver and the digestive system.

While the immediate problem of sulphate transport is resolved by overproducing flavonoids, there’s a distinct downside in the long term. First, of course, is underproduction of tryptophan, with resultant harmful effects on tryptophan-associated processes. It also results in loss of sulphates from the gut, resulting in development of chronic disorders.

Disruption of Cytochrome P450 Enzymes

Glyphosate causes an excess build-up of shikimate by inhibiting EPSP synthase, a critical enzyme in the process that leads to the aromatic amino acids. As a consequence, the precursors are sent down other pathways that produce toxic compounds. For example, activity of the enzyme PAL is substantially increased, leading to the release of ammonia.

This appears to be a significant factor in glyphosate’s damaging effects.

At the same time that PAL activity is increased, a side branch of the tryptophan synthesis pathway is opened to synthesize flavonoids. As noted before, flavonoids’ metabolic function is not yet understood, so their benefits may not be the whole story.

Cytochrome P450 (CYP) is a large family of enzymes that catalyze the oxidation of organic substances and is critical for detoxing xenobiotics. It’s been established since 1998 that glyphosate inhibits CYP in plants. Therefore, it follows that their detoxing function is disrupted.

Retinoic acid is catabolized (destroyed) by a CYP enzyme called CYP26A1. Though retinoic acid is required for the process of developing neural differentiation, the neuron cannot mature until retinoic acid is removed by CYP26A1. Therefore, glyphosate’s inhibition of the CYP enzyme prevents the neuron from maturing.

CYP enzymes function throughout the body, both inside cells and through the bloodstream. Glyphosate is also carried in the blood. Thus, by inhibiting their function, glyphosate can disrupt any activity in which CYP enzymes are active. This is of particular concern in blood clotting, where two CYP enzymes are involved. Thromboxane A2 synthase (CYP5A1) regulates clotting and prostacyclin synthase (CYP8A1) regulates hemorraging. Glyphosate in the blood can inhibit these enzymes, thus disturbing the delicate balance of blood clotting and dissolution.

Endothelial nitric oxide synthase (eNOS) is a member of the CYP family. It’s important for production of nitric oxide (NO), which is needed to relax blood vessels to ease blood flow.

Though not yet documented, it’s predicted that glyphosate disrupts the production of sulphate by eNOS in the endothelium, further exacerbating the sulphate transport concern.

Evidence of CYP Enzyme Inhibition

Multiple evidence from several areas demonstrates that glyphosate inhibits CYP enzyme activity. It inhibits aromatase, which is a CYP enzyme that’s key in converting testosterone to estrogen. Retinoic acid activity is enhanced, which can be explained by suppression of the CYP enzyme that breaks it down. Studies document that glyphosate suppresses certain detoxifyng CYP enzymes.

Two studies demonstrate that activity of CYP19, aromatase, is inhibited by glyphosate. It takes only 10 parts per thousand to disrupt aromatase’s activity in a human liver cell line. At concentrations just one-hundredth the recommended agricultural use, aromatase is inhibited in human placental cells. Worse, when glyphosate is combined with chemicals in RoundUp, these effects happen with just 1/20 as much glyphosate.

In another study, a 15 micromoles concentration of glyphosate resulted in cutting the activity of benzene-detoxing CYP enzymes to one-fourth of normal. When the concentration was increased to 35 micromoles of glyphosate, the CYP activity was completely stopped.

A compelling study documented that rats given glyphosate intragastrically for two weeks suffer a reduction of CYP activity in the liver. This result is not surprising, since glyphosate is an organophosphate, and it’s well established that this class of pesticides inhibits CYP enzyme function in human liver cells. Therefore, it would be unsurprising to find that glyphosate’s inhibition of CYP liver enzymes that detox benzene could lead to severe adverse effects, since it’s known to cause cancer.

Glyphosate may also be an indirect factor in the ongoing die-off of bees. The class of insecticides called neonicotinoids is known to kill bees. One study has found reduced pollination in genetically modified Roundup-Ready canola compared to organic canola. The authors suspect that a synergistic effect between glyphosate and neonicotinoids is worsening bee die-off.

Pathology Induction by Glyphosate

Gyphosate causes disruption of the shikimate pathway in gut bacteria, which results in a domino effect of pathology. It causes formation of excess shikimate, along with deficiencies of aromatic amino acids in plants.

Aromatic amino acids include phenylalanine, tryptophan, and tyrosine, among others. All three can be in short supply as a result of glyphosate’s enzymatic suppression. Phenylalanine cannot be synthesized in the body and is required for synthesis of tyrosine. Its suppression results in a cascade of adverse effects, including of course, reduction in tyrosine.

Excess ammonia is observed in the cells of plants treated with glyphosate. This is true for both natural and Roundup Ready plants. A likely cause of the excess ammonia is glyphosate-induced increase in the activity of phenylalanine ammonia lyase (PAL), an enzyme found in both plants and microbes that catalyzes release of ammonia. Most of glyphosate’s ability to retard plant growth is probably a result of PAL activity, which produces both toxic ammonia and phenolic compounds.

Glyphosate Effects on Gut Bacteria

Evidence of glyphosate’s disruption of gut bacteria is found in cattle and poultry. Over the last ten to fifteen years, Clostridium botulinum infection has increased in German cattle. Glyphosate is toxic to Enterococcus, a friendly bacterium. This leads to a gut imbalance that favors overgrowth of Clostridium.

Research documents that glyphosate reduces beneficial bacteria and increases pathological bacteria in the gut. Particularly pathogenic strains of drug-resistant Salmonella and Clostridium were found, while beneficial Enterococcus, Bacillus, and Lactobacillus are susceptible to glyphosate. The result is overgrowth of pathogenic bacteria at the expense of beneficial bacteria.

In one instance, pathogenic bacteria do a good turn—but in the end, negate it with a particularly nasty by-product. Antibiotic-resistant Pseudomonas are opportunistic pathogens that can break glyphosate down into metabolically-safe and usable phosphate and carbon. Unfortunately, a by-product of the process is neurotoxic formaldehyde, which can cause amyloid-like misfolding of tau protein in neurons, much like those found in Alzheimer’s brains, among other mischief.

Escherichia coli (E. coli) suffers starvation, energy drain, and shut-down of the shikimate pathway in the presence of glyphosate. A switch to anaerobic fermentation occurs instead of oxidizing glucose (sugar), which is a less efficient method of producing energy. It is reminiscent of changes in soil microbes with glyphosate application.

Frogs and Embryonic Development

In research comparing the effects of pesticides on frogs, glyphosate was unique in being able to destroy tadpoles. Out of four species, two had no survivors, one had almost none, and the overall survival of the four species was 70 percent.

Glyphosate had a synergistic effect with a fungal pathogen, Batrachochotrium dendrobatidis, which reduced survival of tadpoles.

It is probable that glyphosate is a factor in the worldwide disappearance of frogs, and also that embryonic development is disrupted.

Slow Effects in Mammals

Samsel & Seneff state:

An insidious issue with glyphosate is that its toxic effects on mammals take considerable time to be overtly manifested.

Nonetheless, evidence is building in mammalian studies. Research on rats given glyphosate in quantities equivalent to the highest legally-allowed doses demonstrated that they suffered oxidative stress in only 30-90 days.

A long term study examined rats fed genetically modified (GM) maize, nonGM maize without glyphosate, or GM maize with glyphosate. The experiment ran for the rats’ lifetimes, about two years. Unlike previous short-term research that had ended at 3 months. The results were dramatic. Rats fed the genetically-modified glyphosate-treated maize suffered multiple pathologies, including enormous mammary tumors in females, and gastrointestinal, liver, and kidney pathologies in males, which also developed skin and liver carcinomas. Male rats tended to die prematurely of liver and kidney deficiencies.

Roundup is a compound that includes both glyphosate and a surfactant called TN-20. Studies have found that the combination greatly increases glyphosate’s toxicity, resulting in mitochondrial damage, and both apoptic and necrotic cell death. It’s suspected that TN-10 disrupts the integrity of the cell barrier, which allows entry by glyphosate.

The synergistic effects of TN-20 with glyphosate were demonstrated in a study showing that dairy product starter microorganisms were inhibited by Roundup, but not by glyphosate alone. That study’s authors wondered if a recent loss in the biodiversity of raw milk might be caused by Roundup.

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Source:

Samsel, Anthony; Seneff, Stephanie. 2013. “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases.” Entropy 15, no. 4: 1416-1463; doi:10.3390/e15041416

A new study has demonstrated glyphosate’s ability to interfere with gut biota and underlying metabolic functions. The conclusion that glyphosate is a major factor in nearly all modern chronic diseases is inescapable. Here’s how those disturbed metabolic functions are associated with conditions like autism, cancer, and Alzheimer’s disease.

by Heidi Stevenson

This is Part 2 of a three-part series:

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

With the damage done to primary cellular function, it should not be a surprise that glyphosate is implicated in the modern health plague, chronic diseases. It seems likely that virtually all are, at the least, exacerbated by it. Following are discussions of a wide array of these condtions and likely associations with glyphosate.

Please note that the interrelationships among glyphosate’s effects are very complex. Therefore, as much as possible, health conditions are arranged so that associations with glyphosate’s effects can be best understood and repetition is minimized. Nonetheless, some points may seem a bit out of context, while others may appear to be repetitious—though I’ve attempted to reduce such irritations. It should also be noted that this is not a complete listing of diseases and conditions discussed by Samsel & Seneff’s report.

Most important of all, though, are the chilling effects that glyphosate and its symbiotic partner, Roundup, have on the human body.

Cholesterol and Vitamin D Deficiencies

Synthesis and breakdown of both cholesterol and vitamin D (which refers solely to vitamin D3 here) are affected by glyphosate’s effects on CYP enzymes. Though there’s certainly an association between sun avoidance and sunscreen use, it’s likely that part of this epidemic is associated with glyphosate.

The importance of glyphosate’s interference in synthesis of cholesterol cannot be overestimated. Cholesterol provides a wide array of functions throughout the body:

Cholesterol is a precursor for synthesis of vitamin D, bile acids, and every steroid.
Cholesterol is required to build and maintain membranes and membrane fluidity.
Cholesterol is involved in cellular transport.
Cholesterol is involved in cell signalling.
Cholesterol is involved in nerve conduction.
Cholesterol is part of the myelin sheath around nerves.
Cholesterol may act as an antioxident.

It’s not difficult to see that glyphosate’s interruption in cholesterol synthesis can have domino effects throughout the body.

Obesity

Obesity is at the base of much modern ill health. However, a strong argument can be made that the obesity epidemic itself is caused by Agribusiness use of glyphosate. It’s already been proposed that synthetic chemicals in general are behind the obesity epidemic. However, high levels of them are better noted for causing anorexia. Samsel & Seneff, though, argue that glyphosate can be behind both problems.

Tryptophan supply is curtailed by glyphosate. Serotonin is derived from tryptophan. Therefore, it follows that depletion of tryptophan leads to deficiency in serotonin.

But the tryptophan tale is even worse. When inflammation is present, after glyphosate redirects production to flavonoids, the limited tryptophan that is produced faces another glyphosate-induced problem. Gut inflammation causes tryptophan to be converted to kynurenine by lymphoid tissues at the inflamed site. So it’s engulfed by two types of white blood cells, macrophages and neutrophils, for self-protection. Immune cells hoard kynurenine so they can defend themselves against DNA damage.

Although the popular press ties serotonin only to depression, it’s highly significant in obesity. It is the hormone that indicates satiety so that hunger stops. Confirmation of the tryptophan-serotonin connection is confirmed by studies documenting low tryptophan and serotonin levels in obese people.

Sadly, trytophan levels remain low after weight reduction, so it should not be surprising that maintaining weight loss can be so difficult. Obesity is a genuinely pathological condition—a genuine disease, not a character defect.

In an experiment, a strain of endotoxin-producing bacteria was transferred from a human gut to the guts of mice with neither beneficial nor harmful bacteria. During a 16-week period, these mice became obese on a high-fat diet. Lest you think that it was the high-fat aspect that made them obese, the same diet was also fed to normal mice, which didn’t gain weight.

Glyphosate changes the balance of gut bacteria to endotoxin-producers. That fact, in conjunction with the fact that the obesity epidemic has increased along with glyphosate’s increased use, provides a strong prima facie case for glyphosate as a factor in obesity. This same trajectory of obesity has also happened in conjunction with glyphosate introduction in other areas of the world. South Africa, which started using glyphosate in the 1970s, along with Roundup Ready genetically modified crops, has the highest obesity rate in Africa.

Inflammatory Bowel Disease

C. difficile is a known causative agent of inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis. The incidence of C. difficile has increased a great deal in North America over the last few years. A study in Wisconsin showed that, although C. difficile was almost unknown in people with IBDs prior to 2003, it was found in 3% of cases in 2003, 7% in 2004, and 16% in 2005.

It is likely that glyphosate is fueling the growth in people with IBDs infected with C. difficile.

Glyphosate can also lead to IBD through its disturbances of tryptophan production. Normally, tryptophan is taken up by the liver primarily for production of adenosine triphosphate (ATP), which is the chemical produced by cells for energy. Any that isn’t taken up circulates in the blood, making it available to cross the blood-brain barrier (BBB) into the brain, where it’s used to make serotonin and melatonin. As already noted, low serotonin levels can lead to obesity.

Obesity does provide some limited protection against inflammatory disease in the gut. There are two factors providing such protection. One is that adipose (fat storing) tissues can store endotoxin produced by gut bacteria, so the lining is spared inflammatory damage. The other reason may be even more significant. Adipose tissue can supply sulphated steroids.

Unfortunately, though, obesity’s protection against inflammation can be overcome by the disturbance in tryptophan creation and processing. The process is not yet well understood. However, experiments on mice have shown the protective effect of obesity does break down, leading to severe inflammatory bowel disease, bleeding, and diarrhea.

Anorexia/Cachexia

The term anorexia nervosa in this study is better understood to mean simply anorexia, which does not involve the psychological condition of refusing to eat. Anorexia, in this context, refers to an inability to eat instead of refusal, and is more closely related to cachexia, which refers to weakness and wasting of the body. It is an end stage of much disease, including tuberculosis, cancer, and aids.

A typical aspect of IBS is weight loss that results from loss of ability to transport nutrients across a damaged gut barrier. Thus, the processes that can lead to obesity are, paradoxically, the same ones that, when taken to greater extremes, can also lead to anorexia and cachexia.

Glyphosate triggers inflammation in a variety of ways, including tumor necrosis factor α (TNF-α), which promotes muscle breakdown, thus likely being a factor in the cachexia of some chronic diseases.

Autism

It’s now well accepted that gut disease is associated with autism.

As noted earlier, glyphosate’s interference with the shikimate pathway results in overactivity of the enzyme PAL, which leads to excessive ammonia, which plays a toxic role in autistic brains.

The synthesis of ammonia is a byproduct of anaerobic fermentation, and anaerobic Clostridia bacteria are found in excess in the feces of children with autism. In general, by-products of anaerobic bacteria, which include phenols, amines, ammonia, and hydrogen sulphide, are toxic to the bowel.

Hepatic encephalitis—confusion, personality changes, reduced consciousness, and coma resulting from liver failure—is related to autism. The connection is ammonia. Impaired liver function prevents detoxification of ammonia, leading to symptoms of both autism and hepatic encephalitis.

Reduction of serotonin in the brain, which is indirectly caused by glyphosate’s redirection of tryptophan synthesis into flavonoids, is associated with autism:

One study comparing 40 autistic children with normal controls found that 35% of the autistic children had a far lower serum ratio of tryptophan to large neutral amino acids.
Inadequate dietary tryptophan is known to exacerbate autistic children’s anxiety and repetitive behaviors.
Mice genetically designed with a defective gene that reduces availability of serotonin in the brain exhibited autistic-like behaviors.

Methylation impairment is seen in both autism and Alzheimer’s disease. It’s caused by an inadequate supply of methionine. An experiment on carrot cell lines demonstrated several pathologies resulting from glyphosate exposure. They were short of phenylalanine, tryptophan, and tyrosine. On top of that, levels of three other amino acids, serine, glycine, and methionine, are cut by 50-65 percent.

Glyphosate interferes with synthesis of methionine, which is necessary for methylation, clearly indicating a link between glyphosate and both autism and Alzheimer’s disease.

Alzheimer’s Disease

Ammonia, which is synthesized by gut bacteria as a result of glyphosate, plays a toxic role in Alzheimer brains.

Glyphosate fuels the growth of antibiotic-resistant Pseudomonas, which breaks it down into safe chemicals. Unfortunately, a byproduct of the process is formaldehyde, which can induce amyloid-like misfolding of proteins in the brain, a key trait of Alzheimer’s disease.

Lysosomes, structures in cells that break down waste materials, depend on sulphate—but glyphosate disrupts sulphate transfer. Liposomal dysfunction is a major factor in Alzheimer’s disease.

Excess ammonia, already demonstrated to be a problem caused by glyphosate, is a known issue in Alzheimer’s disease.

Glyphosate is a potent chelator of divalent cations, and zinc is one of them. Therefore, it’s likely that zinc is chelated and removed from the system, leading to zinc deficiency, which is noted for causing diarrhea and increasing risk of pneumonia and malaria. Glyphosate also reduces the number of friendly gut bacteria that help absorption of minerals, including iron and zinc.

Zinc is used in the brain in the process of degrading amyloid-β plaques. However, as a result of glyphosate, zinc can be in short order, so these plaques don’t get removed. The result is continued buildup of Alzheimer’s characteristic plaques, thus worsening, or possibly even causing, the condition.

Deficiencies of zinc and copper have been noted as likely factors in Alzheimer’s disease. A South Africa study found that supplementing zinc in Alzheimer’s patients known to be low in zinc did not help. However, when vitamins D and A were also supplemented at the same time, improvements were noted. This ties back to glyphosate’s impairment of CYP enzymes, which are required to synthesize vitamin D.

Parkinson’s Disease

Dopamine is synthesized from tyrosine, which is synthesized from phenylalanine—and phenyalanine is inhibited by glyphosate. Reducing tyrosine and phenylalanine in the diet reduces dopamine concentrations in the brain, so it’s reasonable to assume that reduction of tyrosine by glyphosate’s inhibition of phenylalanine will result in reduction of dopamine.

Parkinson’s disease is characterized by impaired dopamine signaling in the brain, and it has also been associated with several pesticides. Though glyphosate has not been named as one, that may be a result of preconceptions about its safety.

Sulphate deficiency has been noted in the brains of people with Parkinson’s disease, as well as Alzheimer’s and amytrophic lateral sclerosis, which though generally considered hereditary, has been increasing over the last few years. Thus, there is good reason to suspect glyphosate’s complicity in all three of these devastating brain conditions.

Multiple Sclerosis

Molecular mimicry is a theory of some autoimmune disorders. It suggests that abnormal entry into the body of a molecule that is similar to ones found in the body can result in an immune response that identifies normal tissues for attack and destruction because of the resemblance.

Multiple sclerosis (MS) is a disease in which the myelin sheath around nerves is attacked and destroyed by the immune system. MS sufferers often have inflammatory bowel disease. A search of the scientific literature found matching mimics in gut bacteria. Coupled with glyphosate’s ability to cause gut inflammation and leaky gut syndrome, a case can be made that the increasing rate of MS is related to the herbicide.

Liver Disease

Fatty liver disease is a growing threat to health. Nonalcoholic fatty liver disease leads to cirrhosis and liver failure. Several glyphosate-related factors may be involved.

TNF-α and other cytokines, which are triggered by glyphosate, induce liver-damaging inflammation. TNF-α inhibits insulin signaling, which is a factor in metabolic syndrome. Cytokines can induce fibrosis and lipid overloading in the liver.

Of course, obesity is associated with liver disease, and glyphosate can induce obesity.

Sleep Disorders

Typtophan is a precursor of melatonin, which is excreted from the pineal gland, and it’s a major factor in sleep cycle regulation. Glysophate’s disruption of tryptophan production may be a factor in sleep disorders.

Fertility

Zinc, which has been shown in the discussion on Alzheimer’s disease to be diminished by glyphosate, is necessary for male reproduction.

Cholesterol sulphate is essential in fertilization, so glyphosate-induced CYP inhibition, which can interfere with cholesterol production, can interfere with fertilization, helping to explain falling fertility rates.

In 1978, Argentina’s birthrate peaked, and has been in decline since then, but the rate of decline accelerated in the last five years of the 20th century. Roundup Ready soybeans were introduced there in 1996 and spread at an unprecedented rate. Argentina is now the leading soybean producer in the world.

The second largest soybean producer is Brazil, where the fertility rate has dropped from more than 6 per woman to under 2. Like Argentina, in the mid-90s they took to to Roundup Ready soybeans with the associated use of glyphosate. A plague of glyphosate-resistant superweeds has developed, which has resulted in massively increased usage of the herbicide. Since starting to grow genetically modified crops, both a rapid decrease in the birth rate and increase in still births have been noted.

The birth rates in both western Europe and the US have declined for several years. While other factors are certainly at play, it seems probable that glyphosate is also a culprit.

Glyphosate has been shown to interfere with testosterone production. In men, the steroidogenic acute regulatory protein (StAR) is required in the process to synthesize the hormone testosterone. A study on a rat cell line found that very low doses of Roundup interfere with StAR function, and higher doses cause necrosis and apoptosis of rat testicular cells. StAR protein levels were reduced by 90 percent.

Aside from StAR, another enzyme called the side chain cleavage enzyme (P450scc) is required to produce steroids. The research just described also found that Roundup inhibits P450scc activity by 71%.

Interestingly, glyphosate alone did not have this effect. Samsel & Seneff surmise that it was a combination of glyphosate and surfactants acting in synergy that had the effect. Significantly, StAR and P450scc are involved in producing several hormones, not only testosterone. Therefore, Roundup is also likely to have adverse effects not only on fertility, but also on the adrenal glands, which produce the glucocorticoids and mineralocorticoids steroids.

An in vitro study on synthesis of progesterone in testicular Leydig cells compared the effects of several pesticides: Ammo, Banvel, Cotoran, Cyclone, Dual, Fusilade, and Roundup. Only Roundup had an effect, and that effect was significant. It reduced progesterone synthesis as much as 94% in a dose-dependent manner.

Birth Defects

Glyphosate is known to cross the placental barrier, and it has been associated with birth defects. A study of a farming population in Ontario, Canada showed a statistically significant increase in spontaneous late-term abortions associated with exposure to glyphosate at any time during pregnancy.

Glyphosate’s inhibition of CYP enzymes causes an increase in retinoic acid. African clawed frog and chick embryos were exposed to low doses of glyphosate, 1/5,000 of the standard. The result was frog embryos that developed into tadpoles with cranial deformities and chick embryos with microcephaly, abnormally small heads. These defects were traced back to an increase in retinoic acid.

Glyphosate leads to inflammation and inflammation leads to excess reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS can damage DNA during replication, thus disrupting embryo development.

Cell cycle checkpoints exist in the life cycle of cells to verify whether there is any DNA damage before allowing progression to the next stage. This is of great importance in mitosis (cell division) to assure that defects are not passed on. Sea urchins, a very simple form of animal life, are used to study mitosis. Cyclin dependent protein kinases (CDKs) help verify whether cells should progress past checkpoints. A live sea urchin study found that Roundup delays activation of a CDK by dephosphorylation of tyrosine. This indicates a means by which glyphosate can cause birth defects and stillbirths.

Preeclampsia, a life threatening condition of pregnancy, may be caused by inadequate sulphate supply, which is caused by glyphosate. Preeclampsia is becoming a much more common problem in pregnant women.

Cancer

The last thing that glyphosate is generally accused of causing is cancer. That, though, may be far from true. Glysophate’s association with breast cancer is implicated as a result of glyphosate-exposed mice that developed massive breast tumors in a recent study. Breast cancer has recently skyrocketed in the US, with one in three women now expected to develop it.

The fact is that professional pesticide operators who are exposed to glyphosate through their jobs have been found to suffer an increased risk of myeloma, bone marrow tumors known to be associated with disease-causing agents. Glyphosate causes chronic inflammation, which is known to damage DNA. Depleted tryptophan is also linked to DNA impairment.

Multiple myeloma accounts for 15% of all lymphatohematopoietic cancers (cancers of blood and lymph production) and 2% of all cancer deaths in the United States. Glyphosate’s ability to trigger obesity is a likely factor in myeloma incidents.

Impaired sulphation is suggested as a cause of breast cancer because it could lead to slower metabolization of sex hormones, leading to increased breast density, which is associated with cancer. The CYP enzyme, CYP1A2, could be a factor as a result of inhibition by glyphosate, as well as its interference with sulphate transport.

Obesity is associated with breast cancer, which again leads to culpability of glyphosate. Inflammation has also been linked to it, so glyphosate’s ability to trigger inflammation implicates it again.

With so many aspects of glyphosate’s effects coming into play, it certainly shouldn’t be surprising that we’re seeing enormous increases in cancer rates.

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Source:

Glyphosate has likely caused more damage to human health than any other chemical ever produced. Indeed, it is probably a cause of the explosion in chronic diseases. Surely civilization cannot be maintained when the average person is irrevocably ill. This trajectory of human misery must come to an end.

by Heidi Stevenson

This is Part 3 of a three-part series:

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Ubiquity of Glyphosate

Glyphosate was first introduced in 1974 and has become the world’s most dominant herbicide. It’s now generic, so there are many brands and formulations. As a result, it’s virtually ubiquitous, found nearly everywhere on earth. Further driving its use are genetically modified (GM) crops, which were first developed for the purpose of creating glyphosate-tolerant plants, usually known as Roundup Ready. These have resulted in ever-more blatant and free use, especially in the wake of glyphosate-resistant superweeds. Estimates put glyphosate-tolerant GM crops at 90% of all transgene crops.

In the United States alone, the amount and increase in glyphosate’s use is stunning. The following table gives estimated figures in millions of pounds of glyphosate for one year:

Year	2001	2003	2005	2007
Range	85-90	128-133	155-160	180-185

Notice that the amount of use has doubled in just six years.

Exposure to Glyphosate

Samsel & Seneff state:

The Western diet is a delivery system for toxic chemicals used in industrial agriculture. It consists primarily of processed foods based on corn, wheat, soy and sugar, and they’re consumed in high quantities. Chemical residues of insecticides, fungicides and herbicides like glyphosate contaminate the entire diet.

Roundup Ready GM crops have become the mainstay of Agribusiness. These include soy, beet sugar, and corn—which supply the bulk of the processed food industry. High fructose corn syrup, implicated in the diabetes epidemic, is produced mostly with GM corn. Cotton is genetically engineered and its oil has entered the food supply.

Glyphosate is systemic in plants, so it cannot be washed off. If it’s used on a crop, it will be in the food produced from it. All the soy, sugar, cotton, and corn that ends up in packaged foods is carrying glyphosate into our bodies.

Food and dairy animals are raised in concentrated animal feed operations (CAFOs). The bulk of their diets consists of GM grain crops. Grain and sugar crops take up higher levels of glyphosate than other crops. Therefore, the flesh, eggs, and milk of CAFO-raised animals are contaminated with glyphosate, which enters the food pipeline.

Glyphosate is used not only on Roundup Ready crops, but also on glyphosate-sensitive sugar cane and wheat shortly before harvest, when it acts as a dessicant. It’s also used as a dessicant on Roundup Ready sugar beets, canola, and cottonseed for oils, among others.

The perception that glyphosate is not toxic in humans results in difficulty obtaining figures on how much glyphosate ends up in the food supply. The United States Department of Agriculture’s (USDA’s) Pesticide Data Program is voluntary. Searching for information on residues for the year 2010, the most recent year for which data is provided, shows residue levels for all pesticides except glyphosate and another organophosphate, glufosinate. The USDA has simply not monitored residue levels for either of these herbicides, though they will this year (2013), but only for a small sampling of glyphosate residues in soy.

Increasing Limits on Glyphosate Use

Governments have failed to control use of glyphosate. The precautionary principle has not been in evidence anywhere. The drive to use it has increased as the use of glyphosate on Roundup Ready crops, which has driven development of noxious superweeds. Therefore, Agribusiness in the forms of chemical and biotech industries have demanded increased limits on glyphosate residue.

In 1999, the EU and UK, where no GM crops are currently grown for human consumption, increased the limit for soy from 0.1 parts per million to 20 ppm—a 200-fold increase! The US limit for soy is currently the same.

Pressure is now on to increase levels even more. In the EU, industry is pressing for an increase of at least 100 times current residue levels in lentils from 0.1 ppm to 10 ppm, or even 15 ppm. Safety isn’t factored in. Approval levels are based solely on anticipated use, and glyphosate use is being driven massively higher by the noxious superweeds that exist only because of it.

The residue limits for food animals are even worse, and by a huge amount. Animal-feed grass is allowed glyphosate residues of 300 ppm, and animal-feed corn can have glyphosate residues of 400 ppm!

Glyphosate’s Toxicity

It should come as no surprise that sickness is becoming the normal state of health. Chronic diseases, once fairly rare, are now how we live and die. Diseases once seen almost exclusively in the elderly are now being seen in children. Autoimmune and neurological disorders are becoming common.

There are many potentially causative and contributory factors, but glyphosate has generally gotten a pass because it was considered “generally recognized as safe”—GRAS—for its apparently low toxicity. Indeed, short term studies appeared to confirm its innocence. However, long term studies of its effects on health weren’t done until recently. The most insidious factor in glyphosate’s toxicity has been the slow expression of harmful effects. Because of it, studies demonstrating glyphosate’s insidious action inside the body—like those Samsel & Seneff reviewed—have been systematically ignored.

So glyphosate is now the most popular herbicide on earth, and that factor is driving the extent of harm it produces. It isn’t just the fact of its toxicity that’s at issue, it’s the sheer volume of usage.

Samsel & Seneff’s research is blowing away the smokescreen around the harmful effects of this monstrous product. They have provided specifics for how glyphosate can destroy health and produce the modern plague of chronic diseases.

Glyphosate: A Trajectory of Human Misery

The proven and probable effects of glyphosate are manifold. The meteoric rise in chronic diseases and metabolic disorders has occurred during the same time period that glyphosate was introduced, and has followed a trajectory much like that of the herbicide’s massive increase in use.

At some point, officials in power must take their heads out of the sand and address the evidence that ties glyphosate to the epidemic of chronic diseases. Samsel and Seneff have now collected, sorted, and logicially extrapolated on evidence from studies, and they leave little question that there must be an association between the herbicide and the phenomenom of mass ill health.

Samsel and Seneff do not oversell their findings. They clarify that glyphosate is not the only toxin in today’s world. Nonetheless, its known effects on some of the human body’s most basic functions—disruption of gut bacteria, impairment of sulphate transport, and interference with CYP enzyme activity—indicate that, at the very least, glyphosate must have a synergistic effect with other environmental toxins.

It is, therefore, imperative that—at the very least—a moratorium be declared on the use of glyphosate until and unless it can be demonstrated to be safe. Surely it’s long past time to apply the precautionary principle to glyphosate and its partner in synergy, Roundup. The toll in human suffering, not to mention costs to society and economic losses, cannot be allowed to continue.

Surely civilization cannot be maintained when the average person is irrevocably ill. This trajectory of human misery must come to an end.

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Source:

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