Don’t Hold Your Breath – Monsanto May Be in Trouble

30 May 2013 6 Comments

by truthfarmer in Consolidation, FDA, food, food safety, GMO's, USDA, WTO

Knowing how Monsanto controls the “regulatory” agencies at the Federal level, I deeply doubt that anything will come of this. Also, since Senator Roy Blunt got the Monsanto Protection Act passed, there may be little that can be legally done against one of the most evil corporations on the face of the planet. Nonetheless, here is a story that we should be making a ruckus about:

Monsanto Panics as Oregon GM Wheat Scandal Spreads Worldwide

May 30, 2013 in Sustainable Agriculture, by Admin Share with

USDA INVESTIGATING DETECTION OF GENETICALLY ENGINEERED (GE) GLYPHOSATE-RESISTANT WHEAT IN OREGON

The U.S. Department of Agriculture’s (USDA) Animal and Plant Health Inspection Service (APHIS) announced Wednesday that test results of plant samples from an Oregon farm indicate the presence of genetically engineered (GE) glyphosate-resistant wheat plants. Further testing by USDA laboratories indicates the presence of the same GE glyphosate-resistant wheat variety that Monsanto was authorized to field test in 16 states from 1998 to 2005. APHIS launched a formal investigation after being notified by an Oregon State University scientist that initial tests of wheat samples from an Oregon farm indicated the possible presence of GE glyphosate-resistant wheat plants. There are no GE wheat varieties approved for sale or in commercial production in the United States or elsewhere at this time.

As a result of the USDA announcement Japanese authorities have canceled a tender offer to buy wheat from the US and other governments worldwide have threatened to stop all US wheat imports.

The EU Commission has asked the United States how to test for unapproved GM Wheat, a spokesman said, adding that incoming shipments would be tested and blocked if they contained the strain.

The detection of this wheat variety does not pose a food safety concern. The Food and Drug Administration (FDA) completed a voluntary consultation on the safety of food and feed derived from this GE glyphosate-resistant wheat variety in 2004. For the consultation, the developer provided information to FDA to support the safety of this wheat variety. FDA completed the voluntary consultation with no further questions concerning the safety of grain and forage derived from this wheat, meaning that this variety is as safe as non-GE wheat currently on the market.“We are taking this situation very seriously and have launched a formal investigation,” said Michael Firko, Acting Deputy Administrator for APHIS’ Biotechnology Regulatory Services, “Our first priority is to as quickly as possible determine the circumstances and extent of the situation and how it happened. We are collaborating with state, industry, and trading partners on this situation and are committed to providing timely information about our findings. This situation is unacceptable and USDA will put all necessary resources towards this investigation.”

The Plant Protection Act (PPA) provides for substantial penalties for serious infractions. Should APHIS determine that this situation was the result of a violation of the PPA, APHIS has the authority to seek penalties for such a violation including civil penalties up to $1,000,000 and has the authority to refer the matter for criminal prosecution, if appropriate.

APHIS, the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Health and Human Services’ FDA work together to regulate the safe use of organisms derived from modern biotechnology. APHIS regulates the introduction (meaning the importation, interstate movement, and environmental release/field testing) of certain GE organisms that may pose a risk to plant health. EPA regulates pesticides, including plants with plant-incorporated protectants (pesticides intended to be produced and used in a living plant), to ensure public safety. EPA also sets limits on pesticide residues on food and animal feed. FDA has primary responsibility for ensuring the safety of human food and animal feed, as well as safety of all plant-derived foods and feeds. (article source)

Yet Another Perversion

28 May 2013 1 Comment

by truthfarmer in food, GMO's Tags: gmo, human genetic engineering, pineapple, Rose pineapple

It is only a matter of time before they destroy everything good under the sun.

Del Monte, one of the world’s largest growers and distributors of the popular tropical pineapple fruit, has developed a genetically modified pineapple that’s currently being grown in Costa Rica, one of the top pineapple-producing countries. It has just received approval by the USDA for eventual sale in the U.S.

Called “Rosé”, representatives for Del Monte say the GMO fruit is still in a testing phase: “The USDA’s decision does not mean that Rosé is in commercial distribution; it is in a testing phase. Del Monte intends to continue to test Rosé and will communicate more details when appropriate,” Dennis Christou, vice president of marketing in North America for Del Monte said in a statement, adding that, “Del Monte Fresh Produce has a very active research and development program designed to explore new varieties and new agricultural techniques. The results of these research projects may or may not lead to commercialization depending on many factors including regulatory approvals by the relevant governmental authorities where and when applicable.”

According to the website, The Packer, Del Monte submitted its requests for approval from the USDA’s APHIS division (Animal and Plant Health Inspection Service) in July of 2012, and the agency quietly gave its approval of Rosé in January of this year, but a formal public response was only made in late April.

Del Monte’s request for approval describes the GMO Rosé variety as having “rose-colored flesh”, which the company says comes from the addition of genes from “edible plant species, pineapple and tangerine” genetically modified to change the color of the pineapple.

A “food safety consultation” must be completed with the FDA before the pineapples can be imported to the U.S. The Packer reports that as of April 26th, the agency’s list of approved consultations did not show any results connected with Del Monte’s Rosé.

http://www.naturallysavvy.com/natural-and-organic/del-monte-s-gmo-pineapple-approved-in-the-u-s

New Study Shows “Leukemogenic” Properties of the Bt toxin

14 May 2013 2 Comments

by truthfarmer in Conspiracy, Control, Disease, FDA, food, Food Destruction Agency, GMO's Tags: bt, cancer, gmo, monsanto, Round Up

This is a redux on yet another study proving the inherent danger of the genetically modified food supply. With all of the proof behind the dangers of consumption of these aberrations, the only thing I can recommend is that every one grow everything they can and we must plant in defiance of the destruction of decency and integrity in our food. Please, do NOT feed your children this stuff!!! Here is the article:

A new study, yet to receive any media attention, reveals the “leukemogenic” properties of the Bt toxin biopesticides engineered into the vast majority of GMO food crops already within the US food supply.

Last September, the causal link between cancer and genetically modified food was confirmed in a French study, the first independent long-term animal feeding study not commissioned by the biotech corporations themselves. The disturbing details can be found here: New Study Finds GM Corn and Roundup Causes Cancer In Rats

Now, a new study published in the Journal of Hematology & Thromboembolic Diseases indicates that the biopesticides engineered into GM crops known as Bacillus Thuringensis (Bt) or Cry-toxins, may also contribute to blood abnormalities from anemia to hematological malignancies (blood cancers) such as leukemia.[i]

A group of scientists from the Department of Genetics and Morphology, Institute of Biological Sciences, University of Brasilia, Brasilia/DF, Brazil set out to test the purported human and environmental biosafety of GM crops, looking particularly at the role that the Bt toxin found within virtually all GM food crops plays on non-target or non-insect animal species.

The research was spurred by the Brazilian Collegiate Board of Directors of the National Sanitary Surveillance Agency (ANVISA), who advocated in 2005 for evaluations of toxicity and pathogenicity of microbiological control agents such as Bt toxins, given that little is known about their toxicological potential in non-target organisms, including humans.

While Bacillus Thurigensis spore-crystals have been used since the late 1960’s in agriculture as a foliar insecticide, it was only after the advent of recombinant DNA biotechnology that these toxin-producing genes (known as delta endotoxins) were first inserted into the plants themselves and released into commercial production in the mid-90’s, making their presence in the US food supply and the bodies of exposed populations ubiquitous.

What the new study revealed is that various binary combinations and doses of Bt toxins are capable of targeting mammalian cells, particularly the erythroid (red blood cell) lineage, resulting in red blood cell changes indicative of significant damage, such as anemia. In addition, the study found that Bt toxins suppressed bone marrow proliferation creating abnormal lymphocyte patterns consistent with some types of leukemia.

The researchers also found that one of the prevailing myths about the selective toxicity of Bt to insects, the target species, no longer holds true:

It has been reported that Cry toxins exert their toxicity when activated at alkaline pH of the digestive tract of susceptible larvae, and, because the physiology of the mammalian digestive system does not allow their activation, and no known specific receptors in mammalian intestinal cells have been reported, the toxicity these MCAs to mammals would negligible [8,22,23]. However, our study demonstrated that Bt spore-crystals genetically modified to express individually Cry1Aa, Cry1Ab, Cry1Ac or Cry2A induced hematotoxicity, particularly to the erythroid lineage. This finding corroborates literature that demonstrated that alkali-solubilized Bt spore-crystals caused in vitro hemolysis in cell lines of rat, mouse, sheep, horse, and human erythrocytes and suggested that the plasma membrane of susceptible cells (erythrocytes, in this case) may be the primary target for these toxins [33]

The study also found:

1) That Cry toxins are capable of exerting their adverse effects when suspended in distilled water, not requiring alkalinization via insect physiology to become activated as formerly believed.

2) That a dose of Cry1Ab as low as 27 mg/kg, their lowest tested dose, was capable of inducing hypochromic anemia in mice – the very toxin has been detected in blood of non-pregnant women, pregnant women and their fetuses in Canada, supposedly exposed through diet.

3) Whereas past reports have found that Bt toxins are generally nontoxic and do not bioaccumulate in fatty tissue or persist in the environment, the new study demonstrated that all Cry toxins tested had a more pronounced effect from 72 hours of exposure onwards, indicating the opposite is true.

4) That high-dose Cry toxin doses caused blood changes indicative of bone marrow damage (damage to “hematopoietic stem cell or bone marrow stroma”).

The authors noted their results “demonstrate leukemogenic activity for other spore-crystals not yet reported in the literature.”

They concluded:

[R]esults showed that the Bt spore-crystals genetically modified to express individually Cry1Aa, Cry1Ab, Cry1Ac or Cry2A can cause some hematological risks to vertebrates,increasing their toxic effects with long-term exposure. Taking into account the increased risk of human and animal exposures to significant levels of these toxins, especially through diet, our results suggest that further studies are required to clarify the mechanism involved in the hematotoxicity found in mice, and to establish the toxicological risks to non-target organisms, especially mammals, before concluding that these microbiological control agents are safe for mammals.

Did you get that? Their conclusion is that it is premature to consider GM toxins to be safe in mammals. Billions have already been exposed to Bt toxins, in combination with glyphosate-based herbicide formulations such as Roundup, and yet, most biotech research scientists and industry regulators still claim they are unequivocally safe. This has much to do with the well-known relationship that biotech corporations like Monsanto have with so-called ‘check book’ science firms who are basically paid to obfuscate adverse health outcomes of their products, such as the GMO-Cancer link. [see: Monsanto-Funded Science Denies Emerging Roundup Cancer Link]

Consider also that the question of combined toxicity of Cry toxins and glyphosate-based residues within plants have not been sufficiently explored, and that glyphosate exposure has already been linked to non-Hodgkins lymphoma and hairy cell leukemia in the biomedical literature.[ii]

The reality is that we no longer have time to wait around for additional research to accumulate on the adverse health effects of GMOs, especially considering the biotech industry has far more capital to infuse into their own faux research on the topic.

Some, in fact, argue that we should not be waiting around for the corrupt legislative process to compel manufacturers to label GMOs, rather, we should be fighting to BAN THEM NOW, advocating for the precautionary principle before its too late.

In the meantime, you can join the growing movement to March Against Monsanto, occurring world wide on May 25th, as a way of expressing your desire for real change, as well as vote with your forks, the only immediately effective tool we have against biological and environmental gene-ocide articulated by the dominant GMO-based food system.

(from GeenMedInfo)

Raw Milk is Not Local Food???

14 May 2013 3 Comments

by truthfarmer in food, No Food Rights, raw milk Tags: Dan Brown, food freedom, FTCLDF, local food, Maine, raw milk

A few years ago, the State of Maine passed several local food freedom ordinances and I was very excited by their success and commitment. Although there was a little problem with their ordinances, they were mostly very positive, and with Maine’s “home rule” authority, it looked like there might be hope in this type of action. First of all, it was local, and local seems to be one type of politics we can actually have a positive effect on. Well guess what? Apparently even if we get our freedom to choose our own food into statute or ordinance, it’s irrelevant to the the courts and the federally controlled State governments.

In Maine, the State went after a giant dairy farmer, Dan Brown, who milked one or two cows and sold his milk locally. Here’s the outcome from Farm To Consumer Legal Defense Fund:

Dan Brown Hearing in Maine Food Sovereignty Case: Judge Finds Raw Milk Not a ‘Local Food’

by admin on May 7, 2013

This is a rewrite of the April 30th original and the May 4th revision. More about the Case

In an incredible decision rendered on May 1st, the Hancock County Superior Court ruled against farmer Dan Brown on his motion for summary judgment. The Court instead granted summary judgment in favor of the State of Maine and issued an injunction enjoining Mr. Brown from selling raw milk and other food products from his farm stand.

The State had alleged that Dan was (1) selling raw milk without being in possession of a milk distributor’s license, (2) selling raw milk without having the necessary warning label, and (3) selling other foods prepared in his home kitchen without being in possession of a retail food license. Dan had argued that for over 30 years the Department of Agriculture had a policy of allowing small, unlicensed milk producers like him sell raw milk from their farm as long as they did not advertise or solicit the sale. He also argued that the Town of Blue Hill, Maine’s local ordinance exempted him from licensing requirements. Dan was represented by General Counsel Gary Cox and his Ellsworth, Maine co-counsel Sandy Collier who argued the case on his behalf.

Blue Hill’s local ordinance provides, in part, that local food produced by a farmer and sold to a consumer for home consumption need not be licensed or inspected. The Court, however, concluded that “nothing in the Blue Hill ordinance clearly states that the town intended to include milk within the definition of local food.” What’s clear is that the judge disregarded the definitions section of the Blue Hill Ordinance:

(c) “Local Foods ” means any food or food product that is grown, produced, or processed by individuals who sell directly to their patrons through farm-based sales or buying clubs, at farmers markets, roadside stands, fundraisers or at community social events.

(d) “Processor ” means any individual who processes or prepares products of the soil or animals for food or drink.

(e) “Producer ” means any farmer or gardener who grows any plant or animalfor food or drink.

FTCLDF member Dan Brown flanked by Attorneys
Gary Cox and Sandy Collier

Dan’s case has been described as a test case in Maine, a state where several local food sovereignty ordinances have been passed in an effort to allow local control over the production, distribution and consumption of local foods. Unfortunately, the Court’s ruling is another example of why the public citizenry loses faith in government when it cannot obtain redress from the judicial system and why more farmers and consumers are resorting to civil disobedience as a means of asserting their rights.

A penalty hearing has been set for May 16th at 9:00 am. At that time the court will determine the appropriate amount of civil penalty to be imposed for the violations alleged in the State’s complaint.

Killing Us Softly – Glyphosphate, Deadly Convenience

02 May 2013 1 Comment

by truthfarmer in Consolidation, Conspiracy, Control, Dairy, Disease, FDA, food, food safety, Uncategorized, USDA Tags: agribusiness, disease, glyphosphate, GMO's, monsanto, Round Up, Seralini

Recently, I posted a link to a study heavily referenced in the following articles. That study actually cinched me up, when not much does any more. The issue I keyed on was the actual change of messenger RNA upon exposure, not limited to ingestion, of the lovely GMO’s that are so prevalent in our food supply now. However, there is a lot more information in the study than just that, and Heidi Stevenson has done a tremendous service to all of mankind by relating the study to us in a three part series on glyphosphate.

Please people, read this. Share it. Give it to mothers who are feeding their babies commercial formula, to farmers growing GMO crops, your local Health Board, doctors, and of course, advocates for real food. I know this is long, but here is a link to a pdf of the three articles so you can print it out and read it at your leisure.

While the truth may be ugly, and unfathomable to those of us who actually love life, it is paramount that we have as much information as possible so we can make decisions based on facts and not simply convenience.

Glyphosphate- Killing Us Softly, Monsanto Style

Glyphosate is assumed to be safe for humans. As a result, it’s become the world’s best-selling herbicide. However, a groundbreaking study documents that it may actually be fueling the plague of chronic & immune diseases, including cancer and autism. This study documents the underlying systemic damage produced by glyphosate, then discusses how that damage leads to specific diseases.

by Heidi Stevenson

This article is split into three parts. This is Part 1, Glyphosate: Chronic Disease Degeneration. It gives an overview and then goes on to discuss the primary findings of a new study about the human effects of Monsanto’s herbicide, glyphosate. Part 2, titled Glyphosate: Disease Creator, discusses specific diseases, applying the basic harms produced by glyphosate and showing how they lead to each disease. Part 3, titled Glyphosate: A Trajectory of Human Misery, discusses glyphosate’s use throughout the world and then draws conclusions.

Monsanto’s herbicide, glyphosate, has become virtually ubiquitous based on a presumption of harmlessness in humans. In spite of noxious and aggressive superweeds that have developed in response and a host of reports citing harm and potential harm to the environment and farm animals, this premise of innocence has resulted in its use nearly everywhere. Because of that same image of innocence, its use has multiplied astronomically.

However, a new report from the journal Entropy turns the proposition of glyphosate’s innocence in human health upside down. An exhaustive review of existing research in which 287 studies were reviewed, coupled with irrefutable logic, produces a frightening picture of the reality: Glyphosate may be the single most devastating substance ever introduced into agribusiness. As the authors, Anthony Samsel and Stephanie Seneff, concluded:

Glyphosate is likely to be pervasive in our food supply, and, contrary to being essentially nontoxic, it may in fact be the most biologically disruptive chemical in our environment.

The range of diseases that can be associated with glyphosate is frightening. Its biological effects are so primary that virtually every bodily system—if not every one—is adversely affected. The authors state:

Our systematic search of the literature has led us to the realization that many of the health problems that appear to be associated with a Western diet could be explained by biological disruptions that have already been attributed to glyphosate. These include digestive issues, obesity, autism, Alzheimer’s disease, depression, Parkinson’s disease, liver diseases, and cancer, among others. While many other environmental toxins obviously also contribute to these diseases and conditions, we believe that glyphosate may be the most significant environmental toxin …

Glyphosate’s Metabolic Disruptions

The study documents that glyphosate disrupts several significant basic biological processes in humans with devastating results. Certain primary functions at the most basic levels are disrupted or diverted. These include:

Disruption of the shikimate pathway in gut biota.
Disruption of sulphate transport
Increase in Flavonoid Synthesis
Disruption of cytochrome P-450 enzymes

This section will explain and discuss each of these.

Shikimate Pathway Disruption

Glyphosate is believed to operate by disrupting the shikimate (pronounced shə kih mut) pathway in plants, a process for manufacturing a group of amino acids called aromatic (though the term has nothing to do with odor). These include phenylalanine, tyrosine, and tryptophan. Aromatic amino acids are required for a plant’s survival.

It’s been assumed that glyphosate is harmless in humans because the shikimate pathway does not exist in any animal. However, the shikimate pathway does exist in bacteria, including those in the mammalian gut. Until fairly recently, the importance of gut biota in health has largely been ignored. However, it’s now understood to be key in many aspects of the body’s function.

Gut bacteria are in a symbiotic relationship with the body. They digest food, synthesize vitamins, detoxify foreign substances, and are key in immune system function and gut permeability. Thus, anything that interferes with the shikimate pathway has the potential of causing severe harm.

Disruption of Sulphate Transport

Sulphate transport, the method by which sulphate is moved into and out of cells, is a delicate balance. When glyphosate is present, this balance becomes a tightrope walk. The problem is that both sulphate and glyphosate are kosmotropes, which can have a devastating impact on the blood.

A kosmotrope is a substance that can cause water to become gelled. Too much sulphate in blood can turn it into sludge, so it cannot circulate and bring nutrients and oxygen to cells or remove waste. Therefore, transport of sulphate is always a balancing act between cellular requirements and blood viscosity.

However, when glyphosate is added to the picture, the risk is even greater. Glyphosate is also a kosmotrope, which makes it significantly more difficult for sulphate to be transported where it’s needed. As a result, sulphate transport is disrupted in the presence of glyphosate.

Increase in Flavonoid Synthesis

Glyphosate interferes with synthesis of the aromatic amino acid, tryptophan, instead favoring the production of flavonoids by as much as 20 times normal. While flavonoids are generally believed to be health-inducing, Samsel & Seneff’s paper presents the likelihood that the picture is far more complex, and they propose a role for them in sulphate transport in the presence of glyphosate.

It’s known that, in both plants and microbes, glyphosate induces synthesis of two kinds of phenols: monophenolic compounds and polyphenolic flavonoids. Although monophenols are known to be toxic, flavonoids are generally thought to be beneficial for heath. However, their metabolic mechanisms are unknown.

Carbon rings are part of the molecular structure of phenols. Molecules with carbon rings have a special capability. They can diffuse the effects of kosmotropes. Therefore, phenols, including monophenols and flavonoids, are able to diffuse the effects of sulphate by binding to it and escorting it through the bloodstream.

Sulphate transport comes under pressure in the face of glysophate’s kosmotropic gelling effect on the blood. Therefore, aromatic amino acids may be oxidized into phenolic compounds to compensate, that is, to provide more phenols for sulphate transport.

However, once a phenol has delivered its sulphate, it becomes highly toxic. Sulphate-free phenols are destructive to phospholipids and DNA.

Therefore, to fulfill the more pressing need of sulphate transport, authors Samsel & Seneff propose that flavonoids are synthesized instead of tryptophan. That is, because of flavonoids’ ability to counter the kosmotropic effects of glyphosate, they are produced at the expense of tryptophan.

They propose that, in the presence of glyphosate, flavonoids and phenols can transport sulphur from the gut to the liver, and then return to the gut by way of the hepatic portal vein to repeat the process. However, once a phenol has given up the sulphate anion in the liver, it becomes toxic, over time causing damage to the liver and the digestive system.

While the immediate problem of sulphate transport is resolved by overproducing flavonoids, there’s a distinct downside in the long term. First, of course, is underproduction of tryptophan, with resultant harmful effects on tryptophan-associated processes. It also results in loss of sulphates from the gut, resulting in development of chronic disorders.

Disruption of Cytochrome P450 Enzymes

Glyphosate causes an excess build-up of shikimate by inhibiting EPSP synthase, a critical enzyme in the process that leads to the aromatic amino acids. As a consequence, the precursors are sent down other pathways that produce toxic compounds. For example, activity of the enzyme PAL is substantially increased, leading to the release of ammonia.

This appears to be a significant factor in glyphosate’s damaging effects.

At the same time that PAL activity is increased, a side branch of the tryptophan synthesis pathway is opened to synthesize flavonoids. As noted before, flavonoids’ metabolic function is not yet understood, so their benefits may not be the whole story.

Cytochrome P450 (CYP) is a large family of enzymes that catalyze the oxidation of organic substances and is critical for detoxing xenobiotics. It’s been established since 1998 that glyphosate inhibits CYP in plants. Therefore, it follows that their detoxing function is disrupted.

Retinoic acid is catabolized (destroyed) by a CYP enzyme called CYP26A1. Though retinoic acid is required for the process of developing neural differentiation, the neuron cannot mature until retinoic acid is removed by CYP26A1. Therefore, glyphosate’s inhibition of the CYP enzyme prevents the neuron from maturing.

CYP enzymes function throughout the body, both inside cells and through the bloodstream. Glyphosate is also carried in the blood. Thus, by inhibiting their function, glyphosate can disrupt any activity in which CYP enzymes are active. This is of particular concern in blood clotting, where two CYP enzymes are involved. Thromboxane A2 synthase (CYP5A1) regulates clotting and prostacyclin synthase (CYP8A1) regulates hemorraging. Glyphosate in the blood can inhibit these enzymes, thus disturbing the delicate balance of blood clotting and dissolution.

Endothelial nitric oxide synthase (eNOS) is a member of the CYP family. It’s important for production of nitric oxide (NO), which is needed to relax blood vessels to ease blood flow.

Though not yet documented, it’s predicted that glyphosate disrupts the production of sulphate by eNOS in the endothelium, further exacerbating the sulphate transport concern.

Evidence of CYP Enzyme Inhibition

Multiple evidence from several areas demonstrates that glyphosate inhibits CYP enzyme activity. It inhibits aromatase, which is a CYP enzyme that’s key in converting testosterone to estrogen. Retinoic acid activity is enhanced, which can be explained by suppression of the CYP enzyme that breaks it down. Studies document that glyphosate suppresses certain detoxifyng CYP enzymes.

Two studies demonstrate that activity of CYP19, aromatase, is inhibited by glyphosate. It takes only 10 parts per thousand to disrupt aromatase’s activity in a human liver cell line. At concentrations just one-hundredth the recommended agricultural use, aromatase is inhibited in human placental cells. Worse, when glyphosate is combined with chemicals in RoundUp, these effects happen with just 1/20 as much glyphosate.

In another study, a 15 micromoles concentration of glyphosate resulted in cutting the activity of benzene-detoxing CYP enzymes to one-fourth of normal. When the concentration was increased to 35 micromoles of glyphosate, the CYP activity was completely stopped.

A compelling study documented that rats given glyphosate intragastrically for two weeks suffer a reduction of CYP activity in the liver. This result is not surprising, since glyphosate is an organophosphate, and it’s well established that this class of pesticides inhibits CYP enzyme function in human liver cells. Therefore, it would be unsurprising to find that glyphosate’s inhibition of CYP liver enzymes that detox benzene could lead to severe adverse effects, since it’s known to cause cancer.

Glyphosate may also be an indirect factor in the ongoing die-off of bees. The class of insecticides called neonicotinoids is known to kill bees. One study has found reduced pollination in genetically modified Roundup-Ready canola compared to organic canola. The authors suspect that a synergistic effect between glyphosate and neonicotinoids is worsening bee die-off.

Pathology Induction by Glyphosate

Gyphosate causes disruption of the shikimate pathway in gut bacteria, which results in a domino effect of pathology. It causes formation of excess shikimate, along with deficiencies of aromatic amino acids in plants.

Aromatic amino acids include phenylalanine, tryptophan, and tyrosine, among others. All three can be in short supply as a result of glyphosate’s enzymatic suppression. Phenylalanine cannot be synthesized in the body and is required for synthesis of tyrosine. Its suppression results in a cascade of adverse effects, including of course, reduction in tyrosine.

Excess ammonia is observed in the cells of plants treated with glyphosate. This is true for both natural and Roundup Ready plants. A likely cause of the excess ammonia is glyphosate-induced increase in the activity of phenylalanine ammonia lyase (PAL), an enzyme found in both plants and microbes that catalyzes release of ammonia. Most of glyphosate’s ability to retard plant growth is probably a result of PAL activity, which produces both toxic ammonia and phenolic compounds.

Glyphosate Effects on Gut Bacteria

Evidence of glyphosate’s disruption of gut bacteria is found in cattle and poultry. Over the last ten to fifteen years, Clostridium botulinum infection has increased in German cattle. Glyphosate is toxic to Enterococcus, a friendly bacterium. This leads to a gut imbalance that favors overgrowth of Clostridium.

Research documents that glyphosate reduces beneficial bacteria and increases pathological bacteria in the gut. Particularly pathogenic strains of drug-resistant Salmonella and Clostridium were found, while beneficial Enterococcus, Bacillus, and Lactobacillus are susceptible to glyphosate. The result is overgrowth of pathogenic bacteria at the expense of beneficial bacteria.

In one instance, pathogenic bacteria do a good turn—but in the end, negate it with a particularly nasty by-product. Antibiotic-resistant Pseudomonas are opportunistic pathogens that can break glyphosate down into metabolically-safe and usable phosphate and carbon. Unfortunately, a by-product of the process is neurotoxic formaldehyde, which can cause amyloid-like misfolding of tau protein in neurons, much like those found in Alzheimer’s brains, among other mischief.

Escherichia coli (E. coli) suffers starvation, energy drain, and shut-down of the shikimate pathway in the presence of glyphosate. A switch to anaerobic fermentation occurs instead of oxidizing glucose (sugar), which is a less efficient method of producing energy. It is reminiscent of changes in soil microbes with glyphosate application.

Frogs and Embryonic Development

In research comparing the effects of pesticides on frogs, glyphosate was unique in being able to destroy tadpoles. Out of four species, two had no survivors, one had almost none, and the overall survival of the four species was 70 percent.

Glyphosate had a synergistic effect with a fungal pathogen, Batrachochotrium dendrobatidis, which reduced survival of tadpoles.

It is probable that glyphosate is a factor in the worldwide disappearance of frogs, and also that embryonic development is disrupted.

Slow Effects in Mammals

Samsel & Seneff state:

An insidious issue with glyphosate is that its toxic effects on mammals take considerable time to be overtly manifested.

Nonetheless, evidence is building in mammalian studies. Research on rats given glyphosate in quantities equivalent to the highest legally-allowed doses demonstrated that they suffered oxidative stress in only 30-90 days.

A long term study examined rats fed genetically modified (GM) maize, nonGM maize without glyphosate, or GM maize with glyphosate. The experiment ran for the rats’ lifetimes, about two years. Unlike previous short-term research that had ended at 3 months. The results were dramatic. Rats fed the genetically-modified glyphosate-treated maize suffered multiple pathologies, including enormous mammary tumors in females, and gastrointestinal, liver, and kidney pathologies in males, which also developed skin and liver carcinomas. Male rats tended to die prematurely of liver and kidney deficiencies.

Roundup is a compound that includes both glyphosate and a surfactant called TN-20. Studies have found that the combination greatly increases glyphosate’s toxicity, resulting in mitochondrial damage, and both apoptic and necrotic cell death. It’s suspected that TN-10 disrupts the integrity of the cell barrier, which allows entry by glyphosate.

The synergistic effects of TN-20 with glyphosate were demonstrated in a study showing that dairy product starter microorganisms were inhibited by Roundup, but not by glyphosate alone. That study’s authors wondered if a recent loss in the biodiversity of raw milk might be caused by Roundup.

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Source:

Samsel, Anthony; Seneff, Stephanie. 2013. “Glyphosate’s Suppression of Cytochrome P450 Enzymes and Amino Acid Biosynthesis by the Gut Microbiome: Pathways to Modern Diseases.” Entropy 15, no. 4: 1416-1463; doi:10.3390/e15041416

A new study has demonstrated glyphosate’s ability to interfere with gut biota and underlying metabolic functions. The conclusion that glyphosate is a major factor in nearly all modern chronic diseases is inescapable. Here’s how those disturbed metabolic functions are associated with conditions like autism, cancer, and Alzheimer’s disease.

by Heidi Stevenson

This is Part 2 of a three-part series:

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

With the damage done to primary cellular function, it should not be a surprise that glyphosate is implicated in the modern health plague, chronic diseases. It seems likely that virtually all are, at the least, exacerbated by it. Following are discussions of a wide array of these condtions and likely associations with glyphosate.

Please note that the interrelationships among glyphosate’s effects are very complex. Therefore, as much as possible, health conditions are arranged so that associations with glyphosate’s effects can be best understood and repetition is minimized. Nonetheless, some points may seem a bit out of context, while others may appear to be repetitious—though I’ve attempted to reduce such irritations. It should also be noted that this is not a complete listing of diseases and conditions discussed by Samsel & Seneff’s report.

Most important of all, though, are the chilling effects that glyphosate and its symbiotic partner, Roundup, have on the human body.

Cholesterol and Vitamin D Deficiencies

Synthesis and breakdown of both cholesterol and vitamin D (which refers solely to vitamin D3 here) are affected by glyphosate’s effects on CYP enzymes. Though there’s certainly an association between sun avoidance and sunscreen use, it’s likely that part of this epidemic is associated with glyphosate.

The importance of glyphosate’s interference in synthesis of cholesterol cannot be overestimated. Cholesterol provides a wide array of functions throughout the body:

Cholesterol is a precursor for synthesis of vitamin D, bile acids, and every steroid.
Cholesterol is required to build and maintain membranes and membrane fluidity.
Cholesterol is involved in cellular transport.
Cholesterol is involved in cell signalling.
Cholesterol is involved in nerve conduction.
Cholesterol is part of the myelin sheath around nerves.
Cholesterol may act as an antioxident.

It’s not difficult to see that glyphosate’s interruption in cholesterol synthesis can have domino effects throughout the body.

Obesity

Obesity is at the base of much modern ill health. However, a strong argument can be made that the obesity epidemic itself is caused by Agribusiness use of glyphosate. It’s already been proposed that synthetic chemicals in general are behind the obesity epidemic. However, high levels of them are better noted for causing anorexia. Samsel & Seneff, though, argue that glyphosate can be behind both problems.

Tryptophan supply is curtailed by glyphosate. Serotonin is derived from tryptophan. Therefore, it follows that depletion of tryptophan leads to deficiency in serotonin.

But the tryptophan tale is even worse. When inflammation is present, after glyphosate redirects production to flavonoids, the limited tryptophan that is produced faces another glyphosate-induced problem. Gut inflammation causes tryptophan to be converted to kynurenine by lymphoid tissues at the inflamed site. So it’s engulfed by two types of white blood cells, macrophages and neutrophils, for self-protection. Immune cells hoard kynurenine so they can defend themselves against DNA damage.

Although the popular press ties serotonin only to depression, it’s highly significant in obesity. It is the hormone that indicates satiety so that hunger stops. Confirmation of the tryptophan-serotonin connection is confirmed by studies documenting low tryptophan and serotonin levels in obese people.

Sadly, trytophan levels remain low after weight reduction, so it should not be surprising that maintaining weight loss can be so difficult. Obesity is a genuinely pathological condition—a genuine disease, not a character defect.

In an experiment, a strain of endotoxin-producing bacteria was transferred from a human gut to the guts of mice with neither beneficial nor harmful bacteria. During a 16-week period, these mice became obese on a high-fat diet. Lest you think that it was the high-fat aspect that made them obese, the same diet was also fed to normal mice, which didn’t gain weight.

Glyphosate changes the balance of gut bacteria to endotoxin-producers. That fact, in conjunction with the fact that the obesity epidemic has increased along with glyphosate’s increased use, provides a strong prima facie case for glyphosate as a factor in obesity. This same trajectory of obesity has also happened in conjunction with glyphosate introduction in other areas of the world. South Africa, which started using glyphosate in the 1970s, along with Roundup Ready genetically modified crops, has the highest obesity rate in Africa.

Inflammatory Bowel Disease

C. difficile is a known causative agent of inflammatory bowel diseases (IBDs), including Crohn’s disease and ulcerative colitis. The incidence of C. difficile has increased a great deal in North America over the last few years. A study in Wisconsin showed that, although C. difficile was almost unknown in people with IBDs prior to 2003, it was found in 3% of cases in 2003, 7% in 2004, and 16% in 2005.

It is likely that glyphosate is fueling the growth in people with IBDs infected with C. difficile.

Glyphosate can also lead to IBD through its disturbances of tryptophan production. Normally, tryptophan is taken up by the liver primarily for production of adenosine triphosphate (ATP), which is the chemical produced by cells for energy. Any that isn’t taken up circulates in the blood, making it available to cross the blood-brain barrier (BBB) into the brain, where it’s used to make serotonin and melatonin. As already noted, low serotonin levels can lead to obesity.

Obesity does provide some limited protection against inflammatory disease in the gut. There are two factors providing such protection. One is that adipose (fat storing) tissues can store endotoxin produced by gut bacteria, so the lining is spared inflammatory damage. The other reason may be even more significant. Adipose tissue can supply sulphated steroids.

Unfortunately, though, obesity’s protection against inflammation can be overcome by the disturbance in tryptophan creation and processing. The process is not yet well understood. However, experiments on mice have shown the protective effect of obesity does break down, leading to severe inflammatory bowel disease, bleeding, and diarrhea.

Anorexia/Cachexia

The term anorexia nervosa in this study is better understood to mean simply anorexia, which does not involve the psychological condition of refusing to eat. Anorexia, in this context, refers to an inability to eat instead of refusal, and is more closely related to cachexia, which refers to weakness and wasting of the body. It is an end stage of much disease, including tuberculosis, cancer, and aids.

A typical aspect of IBS is weight loss that results from loss of ability to transport nutrients across a damaged gut barrier. Thus, the processes that can lead to obesity are, paradoxically, the same ones that, when taken to greater extremes, can also lead to anorexia and cachexia.

Glyphosate triggers inflammation in a variety of ways, including tumor necrosis factor α (TNF-α), which promotes muscle breakdown, thus likely being a factor in the cachexia of some chronic diseases.

Autism

It’s now well accepted that gut disease is associated with autism.

As noted earlier, glyphosate’s interference with the shikimate pathway results in overactivity of the enzyme PAL, which leads to excessive ammonia, which plays a toxic role in autistic brains.

The synthesis of ammonia is a byproduct of anaerobic fermentation, and anaerobic Clostridia bacteria are found in excess in the feces of children with autism. In general, by-products of anaerobic bacteria, which include phenols, amines, ammonia, and hydrogen sulphide, are toxic to the bowel.

Hepatic encephalitis—confusion, personality changes, reduced consciousness, and coma resulting from liver failure—is related to autism. The connection is ammonia. Impaired liver function prevents detoxification of ammonia, leading to symptoms of both autism and hepatic encephalitis.

Reduction of serotonin in the brain, which is indirectly caused by glyphosate’s redirection of tryptophan synthesis into flavonoids, is associated with autism:

One study comparing 40 autistic children with normal controls found that 35% of the autistic children had a far lower serum ratio of tryptophan to large neutral amino acids.
Inadequate dietary tryptophan is known to exacerbate autistic children’s anxiety and repetitive behaviors.
Mice genetically designed with a defective gene that reduces availability of serotonin in the brain exhibited autistic-like behaviors.

Methylation impairment is seen in both autism and Alzheimer’s disease. It’s caused by an inadequate supply of methionine. An experiment on carrot cell lines demonstrated several pathologies resulting from glyphosate exposure. They were short of phenylalanine, tryptophan, and tyrosine. On top of that, levels of three other amino acids, serine, glycine, and methionine, are cut by 50-65 percent.

Glyphosate interferes with synthesis of methionine, which is necessary for methylation, clearly indicating a link between glyphosate and both autism and Alzheimer’s disease.

Alzheimer’s Disease

Ammonia, which is synthesized by gut bacteria as a result of glyphosate, plays a toxic role in Alzheimer brains.

Glyphosate fuels the growth of antibiotic-resistant Pseudomonas, which breaks it down into safe chemicals. Unfortunately, a byproduct of the process is formaldehyde, which can induce amyloid-like misfolding of proteins in the brain, a key trait of Alzheimer’s disease.

Lysosomes, structures in cells that break down waste materials, depend on sulphate—but glyphosate disrupts sulphate transfer. Liposomal dysfunction is a major factor in Alzheimer’s disease.

Excess ammonia, already demonstrated to be a problem caused by glyphosate, is a known issue in Alzheimer’s disease.

Glyphosate is a potent chelator of divalent cations, and zinc is one of them. Therefore, it’s likely that zinc is chelated and removed from the system, leading to zinc deficiency, which is noted for causing diarrhea and increasing risk of pneumonia and malaria. Glyphosate also reduces the number of friendly gut bacteria that help absorption of minerals, including iron and zinc.

Zinc is used in the brain in the process of degrading amyloid-β plaques. However, as a result of glyphosate, zinc can be in short order, so these plaques don’t get removed. The result is continued buildup of Alzheimer’s characteristic plaques, thus worsening, or possibly even causing, the condition.

Deficiencies of zinc and copper have been noted as likely factors in Alzheimer’s disease. A South Africa study found that supplementing zinc in Alzheimer’s patients known to be low in zinc did not help. However, when vitamins D and A were also supplemented at the same time, improvements were noted. This ties back to glyphosate’s impairment of CYP enzymes, which are required to synthesize vitamin D.

Parkinson’s Disease

Dopamine is synthesized from tyrosine, which is synthesized from phenylalanine—and phenyalanine is inhibited by glyphosate. Reducing tyrosine and phenylalanine in the diet reduces dopamine concentrations in the brain, so it’s reasonable to assume that reduction of tyrosine by glyphosate’s inhibition of phenylalanine will result in reduction of dopamine.

Parkinson’s disease is characterized by impaired dopamine signaling in the brain, and it has also been associated with several pesticides. Though glyphosate has not been named as one, that may be a result of preconceptions about its safety.

Sulphate deficiency has been noted in the brains of people with Parkinson’s disease, as well as Alzheimer’s and amytrophic lateral sclerosis, which though generally considered hereditary, has been increasing over the last few years. Thus, there is good reason to suspect glyphosate’s complicity in all three of these devastating brain conditions.

Multiple Sclerosis

Molecular mimicry is a theory of some autoimmune disorders. It suggests that abnormal entry into the body of a molecule that is similar to ones found in the body can result in an immune response that identifies normal tissues for attack and destruction because of the resemblance.

Multiple sclerosis (MS) is a disease in which the myelin sheath around nerves is attacked and destroyed by the immune system. MS sufferers often have inflammatory bowel disease. A search of the scientific literature found matching mimics in gut bacteria. Coupled with glyphosate’s ability to cause gut inflammation and leaky gut syndrome, a case can be made that the increasing rate of MS is related to the herbicide.

Liver Disease

Fatty liver disease is a growing threat to health. Nonalcoholic fatty liver disease leads to cirrhosis and liver failure. Several glyphosate-related factors may be involved.

TNF-α and other cytokines, which are triggered by glyphosate, induce liver-damaging inflammation. TNF-α inhibits insulin signaling, which is a factor in metabolic syndrome. Cytokines can induce fibrosis and lipid overloading in the liver.

Of course, obesity is associated with liver disease, and glyphosate can induce obesity.

Sleep Disorders

Typtophan is a precursor of melatonin, which is excreted from the pineal gland, and it’s a major factor in sleep cycle regulation. Glysophate’s disruption of tryptophan production may be a factor in sleep disorders.

Fertility

Zinc, which has been shown in the discussion on Alzheimer’s disease to be diminished by glyphosate, is necessary for male reproduction.

Cholesterol sulphate is essential in fertilization, so glyphosate-induced CYP inhibition, which can interfere with cholesterol production, can interfere with fertilization, helping to explain falling fertility rates.

In 1978, Argentina’s birthrate peaked, and has been in decline since then, but the rate of decline accelerated in the last five years of the 20th century. Roundup Ready soybeans were introduced there in 1996 and spread at an unprecedented rate. Argentina is now the leading soybean producer in the world.

The second largest soybean producer is Brazil, where the fertility rate has dropped from more than 6 per woman to under 2. Like Argentina, in the mid-90s they took to to Roundup Ready soybeans with the associated use of glyphosate. A plague of glyphosate-resistant superweeds has developed, which has resulted in massively increased usage of the herbicide. Since starting to grow genetically modified crops, both a rapid decrease in the birth rate and increase in still births have been noted.

The birth rates in both western Europe and the US have declined for several years. While other factors are certainly at play, it seems probable that glyphosate is also a culprit.

Glyphosate has been shown to interfere with testosterone production. In men, the steroidogenic acute regulatory protein (StAR) is required in the process to synthesize the hormone testosterone. A study on a rat cell line found that very low doses of Roundup interfere with StAR function, and higher doses cause necrosis and apoptosis of rat testicular cells. StAR protein levels were reduced by 90 percent.

Aside from StAR, another enzyme called the side chain cleavage enzyme (P450scc) is required to produce steroids. The research just described also found that Roundup inhibits P450scc activity by 71%.

Interestingly, glyphosate alone did not have this effect. Samsel & Seneff surmise that it was a combination of glyphosate and surfactants acting in synergy that had the effect. Significantly, StAR and P450scc are involved in producing several hormones, not only testosterone. Therefore, Roundup is also likely to have adverse effects not only on fertility, but also on the adrenal glands, which produce the glucocorticoids and mineralocorticoids steroids.

An in vitro study on synthesis of progesterone in testicular Leydig cells compared the effects of several pesticides: Ammo, Banvel, Cotoran, Cyclone, Dual, Fusilade, and Roundup. Only Roundup had an effect, and that effect was significant. It reduced progesterone synthesis as much as 94% in a dose-dependent manner.

Birth Defects

Glyphosate is known to cross the placental barrier, and it has been associated with birth defects. A study of a farming population in Ontario, Canada showed a statistically significant increase in spontaneous late-term abortions associated with exposure to glyphosate at any time during pregnancy.

Glyphosate’s inhibition of CYP enzymes causes an increase in retinoic acid. African clawed frog and chick embryos were exposed to low doses of glyphosate, 1/5,000 of the standard. The result was frog embryos that developed into tadpoles with cranial deformities and chick embryos with microcephaly, abnormally small heads. These defects were traced back to an increase in retinoic acid.

Glyphosate leads to inflammation and inflammation leads to excess reactive oxygen species (ROS) and reactive nitrogen species (RNS). Both ROS and RNS can damage DNA during replication, thus disrupting embryo development.

Cell cycle checkpoints exist in the life cycle of cells to verify whether there is any DNA damage before allowing progression to the next stage. This is of great importance in mitosis (cell division) to assure that defects are not passed on. Sea urchins, a very simple form of animal life, are used to study mitosis. Cyclin dependent protein kinases (CDKs) help verify whether cells should progress past checkpoints. A live sea urchin study found that Roundup delays activation of a CDK by dephosphorylation of tyrosine. This indicates a means by which glyphosate can cause birth defects and stillbirths.

Preeclampsia, a life threatening condition of pregnancy, may be caused by inadequate sulphate supply, which is caused by glyphosate. Preeclampsia is becoming a much more common problem in pregnant women.

Cancer

The last thing that glyphosate is generally accused of causing is cancer. That, though, may be far from true. Glysophate’s association with breast cancer is implicated as a result of glyphosate-exposed mice that developed massive breast tumors in a recent study. Breast cancer has recently skyrocketed in the US, with one in three women now expected to develop it.

The fact is that professional pesticide operators who are exposed to glyphosate through their jobs have been found to suffer an increased risk of myeloma, bone marrow tumors known to be associated with disease-causing agents. Glyphosate causes chronic inflammation, which is known to damage DNA. Depleted tryptophan is also linked to DNA impairment.

Multiple myeloma accounts for 15% of all lymphatohematopoietic cancers (cancers of blood and lymph production) and 2% of all cancer deaths in the United States. Glyphosate’s ability to trigger obesity is a likely factor in myeloma incidents.

Impaired sulphation is suggested as a cause of breast cancer because it could lead to slower metabolization of sex hormones, leading to increased breast density, which is associated with cancer. The CYP enzyme, CYP1A2, could be a factor as a result of inhibition by glyphosate, as well as its interference with sulphate transport.

Obesity is associated with breast cancer, which again leads to culpability of glyphosate. Inflammation has also been linked to it, so glyphosate’s ability to trigger inflammation implicates it again.

With so many aspects of glyphosate’s effects coming into play, it certainly shouldn’t be surprising that we’re seeing enormous increases in cancer rates.

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Source:

Glyphosate has likely caused more damage to human health than any other chemical ever produced. Indeed, it is probably a cause of the explosion in chronic diseases. Surely civilization cannot be maintained when the average person is irrevocably ill. This trajectory of human misery must come to an end.

by Heidi Stevenson

This is Part 3 of a three-part series:

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Ubiquity of Glyphosate

Glyphosate was first introduced in 1974 and has become the world’s most dominant herbicide. It’s now generic, so there are many brands and formulations. As a result, it’s virtually ubiquitous, found nearly everywhere on earth. Further driving its use are genetically modified (GM) crops, which were first developed for the purpose of creating glyphosate-tolerant plants, usually known as Roundup Ready. These have resulted in ever-more blatant and free use, especially in the wake of glyphosate-resistant superweeds. Estimates put glyphosate-tolerant GM crops at 90% of all transgene crops.

In the United States alone, the amount and increase in glyphosate’s use is stunning. The following table gives estimated figures in millions of pounds of glyphosate for one year:

Year	2001	2003	2005	2007
Range	85-90	128-133	155-160	180-185

Notice that the amount of use has doubled in just six years.

Exposure to Glyphosate

Samsel & Seneff state:

The Western diet is a delivery system for toxic chemicals used in industrial agriculture. It consists primarily of processed foods based on corn, wheat, soy and sugar, and they’re consumed in high quantities. Chemical residues of insecticides, fungicides and herbicides like glyphosate contaminate the entire diet.

Roundup Ready GM crops have become the mainstay of Agribusiness. These include soy, beet sugar, and corn—which supply the bulk of the processed food industry. High fructose corn syrup, implicated in the diabetes epidemic, is produced mostly with GM corn. Cotton is genetically engineered and its oil has entered the food supply.

Glyphosate is systemic in plants, so it cannot be washed off. If it’s used on a crop, it will be in the food produced from it. All the soy, sugar, cotton, and corn that ends up in packaged foods is carrying glyphosate into our bodies.

Food and dairy animals are raised in concentrated animal feed operations (CAFOs). The bulk of their diets consists of GM grain crops. Grain and sugar crops take up higher levels of glyphosate than other crops. Therefore, the flesh, eggs, and milk of CAFO-raised animals are contaminated with glyphosate, which enters the food pipeline.

Glyphosate is used not only on Roundup Ready crops, but also on glyphosate-sensitive sugar cane and wheat shortly before harvest, when it acts as a dessicant. It’s also used as a dessicant on Roundup Ready sugar beets, canola, and cottonseed for oils, among others.

The perception that glyphosate is not toxic in humans results in difficulty obtaining figures on how much glyphosate ends up in the food supply. The United States Department of Agriculture’s (USDA’s) Pesticide Data Program is voluntary. Searching for information on residues for the year 2010, the most recent year for which data is provided, shows residue levels for all pesticides except glyphosate and another organophosphate, glufosinate. The USDA has simply not monitored residue levels for either of these herbicides, though they will this year (2013), but only for a small sampling of glyphosate residues in soy.

Increasing Limits on Glyphosate Use

Governments have failed to control use of glyphosate. The precautionary principle has not been in evidence anywhere. The drive to use it has increased as the use of glyphosate on Roundup Ready crops, which has driven development of noxious superweeds. Therefore, Agribusiness in the forms of chemical and biotech industries have demanded increased limits on glyphosate residue.

In 1999, the EU and UK, where no GM crops are currently grown for human consumption, increased the limit for soy from 0.1 parts per million to 20 ppm—a 200-fold increase! The US limit for soy is currently the same.

Pressure is now on to increase levels even more. In the EU, industry is pressing for an increase of at least 100 times current residue levels in lentils from 0.1 ppm to 10 ppm, or even 15 ppm. Safety isn’t factored in. Approval levels are based solely on anticipated use, and glyphosate use is being driven massively higher by the noxious superweeds that exist only because of it.

The residue limits for food animals are even worse, and by a huge amount. Animal-feed grass is allowed glyphosate residues of 300 ppm, and animal-feed corn can have glyphosate residues of 400 ppm!

Glyphosate’s Toxicity

It should come as no surprise that sickness is becoming the normal state of health. Chronic diseases, once fairly rare, are now how we live and die. Diseases once seen almost exclusively in the elderly are now being seen in children. Autoimmune and neurological disorders are becoming common.

There are many potentially causative and contributory factors, but glyphosate has generally gotten a pass because it was considered “generally recognized as safe”—GRAS—for its apparently low toxicity. Indeed, short term studies appeared to confirm its innocence. However, long term studies of its effects on health weren’t done until recently. The most insidious factor in glyphosate’s toxicity has been the slow expression of harmful effects. Because of it, studies demonstrating glyphosate’s insidious action inside the body—like those Samsel & Seneff reviewed—have been systematically ignored.

So glyphosate is now the most popular herbicide on earth, and that factor is driving the extent of harm it produces. It isn’t just the fact of its toxicity that’s at issue, it’s the sheer volume of usage.

Samsel & Seneff’s research is blowing away the smokescreen around the harmful effects of this monstrous product. They have provided specifics for how glyphosate can destroy health and produce the modern plague of chronic diseases.

Glyphosate: A Trajectory of Human Misery

The proven and probable effects of glyphosate are manifold. The meteoric rise in chronic diseases and metabolic disorders has occurred during the same time period that glyphosate was introduced, and has followed a trajectory much like that of the herbicide’s massive increase in use.

At some point, officials in power must take their heads out of the sand and address the evidence that ties glyphosate to the epidemic of chronic diseases. Samsel and Seneff have now collected, sorted, and logicially extrapolated on evidence from studies, and they leave little question that there must be an association between the herbicide and the phenomenom of mass ill health.

Samsel and Seneff do not oversell their findings. They clarify that glyphosate is not the only toxin in today’s world. Nonetheless, its known effects on some of the human body’s most basic functions—disruption of gut bacteria, impairment of sulphate transport, and interference with CYP enzyme activity—indicate that, at the very least, glyphosate must have a synergistic effect with other environmental toxins.

It is, therefore, imperative that—at the very least—a moratorium be declared on the use of glyphosate until and unless it can be demonstrated to be safe. Surely it’s long past time to apply the precautionary principle to glyphosate and its partner in synergy, Roundup. The toll in human suffering, not to mention costs to society and economic losses, cannot be allowed to continue.

Surely civilization cannot be maintained when the average person is irrevocably ill. This trajectory of human misery must come to an end.

Part 1, Glyphosate: Chronic Disease Degeneration
Part 2, Glyphosate: Disease Creator
Part 3, Glyphosate: A Trajectory of Human Misery

Source:

Food is the New Money

01 May 2013 Leave a comment

by truthfarmer in Control, food, food shortage Tags: collapse, food control, food is the new money, preparedness

I’ve been saying that for several years now, and it seems to me that it is coming closer to that harsh reality in the global picture.

Lately I have been swamped with State legislative issues and also family issues so I haven’t had much time to do more than try to keep on top of the avalanche of atrocities pouring forth from overarching governmental control and lack of accountability by the perpetrators of the atrocities. So, my apologies for what may appear to be laziness to those who aren’t around me on a daily basis.

However, the following article is tremendously important and may help to rip the scales off some people’s eyes so that they feel moved to at least prepare some additional provisions for themselves and their families. Please share it and encourage people to check the links provided. When it comes right down to it, we all work to eat!

Report: Farmers Hoarding Food To Protect Against Currency Collapse

Mac Slavo
April 29th, 2013

Which asset is more secure than money in the bank?

The answer is simple.

It’s the asset that will still have value when the money or the bank collapse.

All over the world, when people have been faced with the prospect of having their savings wiped out or confiscated they have turned to hard assets – physical goods they could hold in their possession and trade if necessary – as protection.

Argentina, a country that is no stranger to economic hard times and hyperinflation, gives us a prime example of what becomes money when the system collapses.

At an inflation rate of 25%, while their currency loses significant purchasing power, Argentines have made a mad rush into gold, silver, and other tangible goods that retain their barterable value.

Like many Greeks, who have headed to the countryside to grow their own food in the midst of complete economic destruction, farmers in Argentina are hoarding the one tangible investment they know will not lose value, no matter what their currency does.

With world food demand on the rise, growers in the Pampas grain belt are filling their silos with soy rather than converting their crops into pesos, a currency that hit a new all-time low in informal trade this week.

Considering Argentina’s high inflation, clocked at about 25 percent by private economists, “money in the bank” is not as secure as storing soybeans next to their fields, many say.

“We are going to hang onto our soy. One can see higher prices ahead,” said Jose Plazibat, a partner with the firm of Bandurria and Plazibat Brothers, which farms more than 3,000 hectares near the town of Chacabuco in Buenos Aires province.

With their currency in meltdown and food demand around the world rising, these farmers understand where real value comes from.

Their food can’t be lost in the stock market.
It’s intrinsic worth cannot be vaporized in a banking collapse.
And they do not need to wait for anyone to deliver it to them, as they hold it in their personal possession.

Hoarding commodities – not the paper receipts that represent your ownership, but the actual physical good – is a powerful diversification strategy, and one that is a natural response to times of uncertainty and government run amok:

Argentina is going through the classic stages of economic collapse.

The government seized all pensions. They are destroying everything that gives the people incentive to be a society that emerges from the cooperation of everyone.

When government turns against its own people, even as the USA is currently doing, you end up with deflation insofar as the economy collapses and wages are not available, while hoarding emerges as does barter.

source: Martin Armstrong

This strategy of buying commodities at lower prices today to consume at higher prices tomorrow can be implemented on a micro-economic personal scale in your own home. Doing so, especially with health and nutrition considerations, will not only provide you with long-term cost savings as global currencies continue to lose purchasing power, but insulate you against the possibility of a rush for food in the event of an emergency or widespread economic instability.

Whether you choose to stock your long-term food pantry by going to a grocery store, grow your own food in your traditional or aquaponics garden, learn to preserve it yourself, or prefer to do your own food storage packing, the key is to develop a plan and implement it now.

The US dollar isn’t getting any stronger over the next 10 years.

But the rice, beans, wheat, and pasta you stockpile will still have the same exact intrinsic value a decade from now as they do today.

(Link to article source)

Truth IS Stranger Than Fiction…..Again

10 Apr 2013 Leave a comment

by truthfarmer in farm loss, food, GMO's, Uncategorized

Ok, so they kill the bees, buy the leading research group that is determining the cause of death of the bees, and now, Harvard is making robotic bees to replace the real thing. Sheesh. I don’t think robotic honey is going to happen though.

Robotic Bees to Pollinate Monsanto Crops

8APR

by Russ McSpadden / Earth First! Newswire

Pollinators participate in the sexual-reproduction of plants. When you eat an almond, beet, watermelon or sip on coffee, you’re partaking of an ancient relationship between pollinators and flowers. But since the 1990s, worldwide bee health has been in decline and most evidence points to toxic pesticides created by Shell and Bayer and the loss of genetic biodiversity due to the proliferation of GMO monocrops created in laboratories by biotech companies like Monsanto.

But never worry, those real life pollinators—the birds and the bees, as they say—may soon be irrelevant to the food needs of civilization. Harvard roboticists are developing a solution to the crisis: swarms of tiny robot bees made of titanium and plastic that can pollinate those vast dystopian fields of GMO cash crops.

The Harvard Microrobotics Lab has been working on its Micro Air Vehicles Project since early 2009. Borrowing from the biomechanics and social organization of bees, the team of researchers is undergoing the creation of tiny winged robots to fly from flower to flower, immune to the toxins dripping from petals, to spread pollen. They even believe that they will soon be able to program the robobees to live in an artificial hive, coordinate algorithms and communicate amongst themselves about methods of pollination and location of particular crops.

Of course, published reports from the lab also describe potential military uses—surveillance and mapping—but the dime-sized cyber-bees have yet to be outfitted with neurotoxin tipped stingers.

Too Important to Ignore- GMO Gene Silencing and Activation

27 Mar 2013 4 Comments

by truthfarmer in Disease, food, GMO's

I just received this article in which several scientists have found that certain types of genetic modification actually can silence or activate genes upon exposure. In my estimation, this is some pretty dangerous stuff. Considering the Monsanto Protection Act has just passed into law, and Jason Smith in Missouri is pushing for the Constitutional Amendment to protect “agricultural technology”, I’m deeply concerned about this new revelation. Please read the article and do your own study. I just don’t know how we can avoid exposure….Your thoughts are welcome!

New paper on dsRNA risks – briefing for non-specialists

Friday, 22 March 2013 20:15

NOTE: The briefing document below is a summary for the lay person of the paper published yesterday, “A comparative evaluation of the regulation of GM crops or products containing dsRNA and suggested improvements to risk assessment” by Professor Jack Heinemann, Sarah Agapito-Tenfen and Adjunct Associate Professor Judy Carman.

Press release/abstract here:
http://www.gmwatch.org/index.php?option=com_content&view=article&id=14713

The paper is open access (free download), thanks to sponsorship of the open access fee by the Safe Food Institute of Australia:
http://www.sciencedirect.com/science/journal/01604120
—
—
A briefing document for non-specialists describing the lack of regulation of a new class of products and GM crops based on dsRNA technology
by
Adjunct Associate Professor Judy Carman, Professor Jack Heinemann and Sarah Agapito-Tenfen
21 March 2013

This is a briefing about the contents of a new, peer-reviewed scientific paper: “A comparative evaluation of the regulation of GM crops or products containing dsRNA and suggested improvements to risk assessment” by Professor Jack Heinemann, Sarah Agapito-Tenfen and Adjunct Associate Professor Judy Carman.

To date, most[1] genetically modified (GM) plants have been made by inserting a new piece of DNA into a plant so that the GM version makes a new protein. Most of these new proteins are designed to either kill insects that try to eat the plant or to make the plant resistant to a herbicide. The process works like this: the DNA is changed so that when a section of the DNA is read and copied, a new piece of messenger RNA (mRNA) is made. The mRNA then goes to another part of the cell and is read to make the new protein.

However, there is a new type of GM plant now being made. These are not designed to make a new protein, but to just make a new RNA molecule. However, the RNA molecule made is different to the single-stranded mRNA described earlier, because it is either double-stranded (dsRNA) or it is designed to find another single-stranded RNA molecule and bind to it to create a dsRNA molecule. These dsRNA molecules have important roles in cells. For example, they can silence or activate genes. For this to happen, the order of the nucleotide units in the dsRNA molecule is crucial. A different sequence can result in the dsRNA having different effects, and silencing or activating a different gene, or multiple other genes.

A number of GM plants have now been made using this technology. For example, Australia’s CSIRO has developed GM wheat and barley varieties where genes have been silenced in order to change the type of starch made by the plant. Another example is biopesticide plants, which are designed to silence a gene in insects that eat the plant. That is, the insect eats the plant, the dsRNA in the plant survives digestion in the insect, travels into the tissues of the insect to silence a gene in the insect so that the insect dies as a result.

There is evidence that the gene silencing may be inherited by the offspring of some organisms that eat the dsRNA.

Furthermore, there is massive, ongoing investment occurring to develop products that directly transfer dsRNA into the living cells of plants, animals and microbes via their food or by being absorbed through their “skin”. This allows dsRNA molecules to be sprayed onto fields of crops to kill insects or to be delivered to beehives as oral medicine for bees.

Last year, a high profile scientific paper was published that showed that dsRNA molecules produced in non-GM plants can be taken into the bodies of people who eat the plant. The dsRNA from the plant was found circulating in blood, indicating that it survives cooking and digestion. Research has also shown that:

*at least one dsRNA produced in plants (called mir168a) can change the expression of genes in mice; and

*dsRNA (mir168a) can change the expression of a gene in human cells growing in tissue culture. Therefore, there is a real risk that the dsRNA produced by these new GM crops could survive digestion in people and change how those people’s genes are expressed. These effects of dsRNA were predicted long ago by some scientists. The proof has now arrived.

So, are all dsRNA molecules safe?

A new paper has just been published in Environment International by Professor Jack Heinemann of New Zealand, Sarah Agapito-Tenfen of Brazil and Adjunct Associate Professor Judy Carman of Australia. These authors looked at how the safety of some plants, designed to produce new dsRNA, was determined. They reviewed their experience with three government safety regulators (for either food or the environment) in three different countries over the past ten years. They found that the safety of dsRNA molecules was usually not considered at all, and if it was considered in any way, the regulator simply assumed that any dsRNA molecules were safe, rather than requiring proof that they were safe.

The authors found that government regulators:

*dismissed any need for any assessment of the sequence of the nucleotides in the dsRNAs produced by GM plants;
*seemed to assume that dsRNAs produced by these plants are much the same as the more fragile single-stranded RNAs (eg mRNA), and therefore would not survive cooking and digestion; and
*claimed that these new dsRNA molecules are safe because humans and non-target animals would simply not be exposed to them.

However, the authors found many scientific studies showing that these assumptions were incorrect.

As a result, the regulators did not assess whether the dsRNAs could cause adverse effects in people or in the environment by, for example, silencing or activating genes in people that come into contact with the plant when it is grown commercially. Contact could include eating the crop or processed products derived from it, inhaling dust from the crop when harvesting it, or inhaling flour from the crop when baking with it. And regulators made that decision regardless of whether the dsRNA was generated intentionally or unintentionally by the crop. All three regulators decided that there were no risks to be considered, based on their own unproven and incorrect assumptions, rather than the scientific evidence.

As a result of their analysis, the authors developed and provided a safety testing procedure for all GM plants that may produce new dsRNA molecules, as well as for products where the active ingredient is dsRNA.

It is important to realise that our current understanding of dsRNA in GM plants is in its infancy and we are still trying to understand how dsRNA molecules may work and therefore how they may affect humans, animals and the environment. Even so, some GM plants using this technology have already been approved for human consumption, using the sorts of assumptions described earlier. Of these crops, several have been withdrawn from the market, while others are about to enter it.

Meanwhile, spraying dsRNAs directly onto crops can be expected to result in large exposures to dsRNA molecules in the environment. For example, we know that existing agricultural sprays can travel for several miles on the wind and can enter surface water and ground water due to run-off after rain. This will also happen with dsRNA molecules if they are sprayed onto crops. We also know that dsRNAs can persist for a long time in the environment.

GM plants and products based on dsRNA technology need a thorough, fit-for-purpose safety evaluation before we use them commercially. The authors provide a step-by-step procedure of how this could be done.

After all, we don’t want to learn that one or more of these crops or sprays is toxic after millions of people have been exposed to them for years.

Notes

1. There are some extremely minor exceptions to this, such as virus-resistant papaya, some nutritionally- altered soybeans, and some other plants that are not yet on the market.

Guerilla Gardening–Do this!

17 Mar 2013 Leave a comment

by truthfarmer in food, food shortage, Uncategorized Tags: Guerilla Gardening

I just received this link and while I am well aware there are things going on all over the country like the actions taken by this man, I don’t think it is enough. This video should inspire others to join in and reclaim the most basic of all human rights; that being the right to eat food of one’s choice grown in a way one desires to grow it!

Bowman vs Monsanto- David vs Goliath

18 Feb 2013 2 Comments

by truthfarmer in food, GMO's Tags: bowman, monsanto, US Supreme Court

Monsanto is a little bit worried about this decision. I think they have stacked the court pretty well in their favor, but the most critical aspect that is apparent to me is that if you, as Monsanto has done, create a new life form, can you lay claim to their progeny? It would be like parents having the ability to contractually control their great grandchildren. We shall soon see what happens! Here’s a Reuters article on the case:

U.S. agriculture wary as Monsanto heads to Supreme Court

Supreme Court next week in a patent battle that could have ramifications for the biotechnologyindustry and possibly the future of food production.

The highest court in the United States will hear arguments on Tuesday in the dispute, which started when soybean farmer Vernon Bowman bought and planted a mix of unmarked grain typically used for animal feed. The plants that grew turned out to contain the popular herbicide-resistant genetic trait known as Roundup Ready that Monsanto guards closely with patents.

The St. Louis, Mo.-based biotech giant accused Bowman of infringing its patents by growing plants that contained its genetics. But Bowman, who grows wheat and corn along with soybeans on about 300 acres inherited from his father, argued that he used second-generation grain and not the original seeds covered by Monsanto’s patents.

A central issue for the court is the extent that a patent holder, or the developer of a genetically modified seed, can control its use through multiple generations of seed.

The Supreme Court’s decision to hear the dispute has sparked broad concerns in the biotech industry as a range of companies fear it will result in limits placed on their own patents of self-replicating technologies.

At the same time, many farmer groups and biotech crop critics hope the Supreme Court might curb what they say is a patent system that gives too much power to biotech seed companies like Monsanto.

“I think the case has enormous implications,” said Dermot Hayes, an Iowa State University agribusiness and economics professor who believes Monsanto should prevail. “If Monsanto were to lose, many companies would have a reduced incentive for research in an area where we really need it right now. The world needs more food.” (full article here)

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